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Models for Prediction of Factor VIII Half-Life in Severe Haemophiliacs: Distinct Approaches for Blood Group O and Non-O Patients

Author

Listed:
  • Kathelijn Fischer
  • Ronan Pendu
  • Carina J van Schooten
  • Karin van Dijk
  • Cécile V Denis
  • H Marijke van den Berg
  • Peter J Lenting

Abstract

Background: Von Willebrand factor (VWF) is critical for the in vivo survival of factor VIII (FVIII). Since FVIII half-life correlates with VWF-antigen pre-infusion levels, we hypothesized that VWF levels are useful to predict FVIII half-life. Methodology: Standardized half-life studies and analysis of pre-infusion VWF and VWF-propeptide levels were performed in a cohort of 38 patients with severe haemophilia A (FVIII

Suggested Citation

  • Kathelijn Fischer & Ronan Pendu & Carina J van Schooten & Karin van Dijk & Cécile V Denis & H Marijke van den Berg & Peter J Lenting, 2009. "Models for Prediction of Factor VIII Half-Life in Severe Haemophiliacs: Distinct Approaches for Blood Group O and Non-O Patients," PLOS ONE, Public Library of Science, vol. 4(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0006745
    DOI: 10.1371/journal.pone.0006745
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