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Analysis of East Asia Genetic Substructure Using Genome-Wide SNP Arrays

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  • Chao Tian
  • Roman Kosoy
  • Annette Lee
  • Michael Ransom
  • John W Belmont
  • Peter K Gregersen
  • Michael F Seldin

Abstract

Accounting for population genetic substructure is important in reducing type 1 errors in genetic studies of complex disease. As efforts to understand complex genetic disease are expanded to different continental populations the understanding of genetic substructure within these continents will be useful in design and execution of association tests. In this study, population differentiation (Fst) and Principal Components Analyses (PCA) are examined using >200 K genotypes from multiple populations of East Asian ancestry. The population groups included those from the Human Genome Diversity Panel [Cambodian, Yi, Daur, Mongolian, Lahu, Dai, Hezhen, Miaozu, Naxi, Oroqen, She, Tu, Tujia, Naxi, Xibo, and Yakut], HapMap [ Han Chinese (CHB) and Japanese (JPT)], and East Asian or East Asian American subjects of Vietnamese, Korean, Filipino and Chinese ancestry. Paired Fst (Wei and Cockerham) showed close relationships between CHB and several large East Asian population groups (CHB/Korean, 0.0019; CHB/JPT, 00651; CHB/Vietnamese, 0.0065) with larger separation with Filipino (CHB/Filipino, 0.014). Low levels of differentiation were also observed between Dai and Vietnamese (0.0045) and between Vietnamese and Cambodian (0.0062). Similarly, small Fst's were observed among different presumed Han Chinese populations originating in different regions of mainland of China and Taiwan (Fst's

Suggested Citation

  • Chao Tian & Roman Kosoy & Annette Lee & Michael Ransom & John W Belmont & Peter K Gregersen & Michael F Seldin, 2008. "Analysis of East Asia Genetic Substructure Using Genome-Wide SNP Arrays," PLOS ONE, Public Library of Science, vol. 3(12), pages 1-10, December.
    • Handle: RePEc:plo:pone00:0003862
    DOI: 10.1371/journal.pone.0003862
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    References listed on IDEAS

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    1. Chao Tian & Robert M Plenge & Michael Ransom & Annette Lee & Pablo Villoslada & Carlo Selmi & Lars Klareskog & Ann E Pulver & Lihong Qi & Peter K Gregersen & Michael F Seldin, 2008. "Analysis and Application of European Genetic Substructure Using 300 K SNP Information," PLOS Genetics, Public Library of Science, vol. 4(1), pages 1-11, January.
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    1. Takeshi Nishiyama & Hirohisa Kishino & Sadao Suzuki & Ryosuke Ando & Hideshi Niimura & Hirokazu Uemura & Mikako Horita & Keizo Ohnaka & Nagato Kuriyama & Haruo Mikami & Naoyuki Takashima & Keitaro Mas, 2012. "Detailed Analysis of Japanese Population Substructure with a Focus on the Southwest Islands of Japan," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.

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