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Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis

Author

Listed:
  • Adriana Echazu
  • Daniela Bonanno
  • Pedro Emanuel Fleitas
  • Julie Jacobson
  • Gabriela Matamoros
  • Charles Mwandawiro
  • Wendemagegn Enbiale
  • Áuria de Jesus
  • Alan Brooks
  • Alejandro Javier Krolewiecki

Abstract

Background: Ivermectin (IVM) is widely used in mass drug administration (MDA) programs for the control of neglected tropical diseases (NTDs). Current regimens rely on weight- or height-based dosing, which lead to operative challenges. This study evaluates an age-based fixed-dose regimen for IVM. Methodology: This is an individual participant data (IPD) meta-analysis including anthropometric data from over 700,000 individuals, across 53 NTD-endemic countries. Fixed-dose regimens were developed based on weight distribution by age. The proportion of individuals achieving the target range dose (200–400 µg/kg) was assessed and compared to traditional dosing regimens. Principal Findings: Fixed-doses of 3 mg for pre-school children (PSAC), 9 mg for school-aged children (SAC), and 18 mg for women of reproductive age (WRA) resulted in a higher proportion of participants receiving the target dose compared to weight- and height-based regimens (79.9% vs. 32.7% and 37.3%, respectively, p

Suggested Citation

  • Adriana Echazu & Daniela Bonanno & Pedro Emanuel Fleitas & Julie Jacobson & Gabriela Matamoros & Charles Mwandawiro & Wendemagegn Enbiale & Áuria de Jesus & Alan Brooks & Alejandro Javier Krolewiecki, 2025. "Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 19(9), pages 1-19, September.
    • Handle: RePEc:plo:pntd00:0013059
    DOI: 10.1371/journal.pntd.0013059
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