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The global, regional, and national burden of Invasive Non-typhoidal Salmonella (iNTS): An analysis from the Global Burden of Disease Study 1990–2021

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  • Yunjuan He
  • Qingqing Jia
  • Kang Cai
  • Shanshan Xu
  • Huajun Li
  • Qiuling Xie
  • Yushu Qiu
  • Liya Zhang
  • Xianting Jiao

Abstract

Objectives: Invasive Non-typhoidal Salmonella (iNTS) can cause serious, life-threatening, and invasive infections, posing great challenges to public health. We aimed to systematically review the burden of iNTS disease based on Global Burden of Diseases (GBD) 2021. Methods: We extracted data for the incidence, death, and disability-adjusted life-years (DALYs) associated with iNTS from GBD 2021, providing an overview of its epidemiology while examining trends from 1990 to 2021. Additionally, we decomposed changes of iNTS-related burden, and quantified cross-country inequalities. Results: GBD 2021 estimated 509976(95%UI,413361 to 606167) incident cases of iNTS worldwide in 2021, with the most cases and highest age-standardized rate (ASR) in Western Sub-Saharan Africa. The low SDI region had the most cases of iNTS in 2021. The incidence and DALYs rates were highest in the Low SDI region. Among all age groups, the incidence, death, and DALYs rate of iNTS were primarily concentrated among the following age groups:

Suggested Citation

  • Yunjuan He & Qingqing Jia & Kang Cai & Shanshan Xu & Huajun Li & Qiuling Xie & Yushu Qiu & Liya Zhang & Xianting Jiao, 2025. "The global, regional, and national burden of Invasive Non-typhoidal Salmonella (iNTS): An analysis from the Global Burden of Disease Study 1990–2021," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 19(4), pages 1-15, April.
    • Handle: RePEc:plo:pntd00:0012960
    DOI: 10.1371/journal.pntd.0012960
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