IDEAS home Printed from https://ideas.repec.org/a/plo/pntd00/0012407.html

Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies

Author

Listed:
  • Francisco Cezar Aquino de Moraes
  • Maria Eduarda Cavalcanti Souza
  • Lucca Dal Moro
  • Isabelle Batista Donadon
  • Emanuele Rocha da Silva
  • Dilma do Socorro Moraes de Souza
  • Rommel Mario Rodríguez Burbano

Abstract

Background: Maternal-foetal transmission of Chagas disease (CD) affects newborns worldwide. Although Benznidazole and Nifurtimox therapies are the standard treatments, their use during pregnancy is contra-indicated. The effectiveness of trypanocidal medications in preventing congenital Chagas Disease (cCD) in the offsprings of women diagnosed with CD was highly suggested by other studies. Methods: We performed a systematic review and meta-analysis of studies evaluating the effectiveness of treatment for CD in women of childbearing age and reporting frequencies of cCD in their children. PubMed, Scopus, Web of Science, Cochrane Library, and LILACS databases were systematically searched. Statistical analysis was performed using Rstudio 4.2 using DerSimonian and Laird random-effects models. Heterogeneity was examined with the Cochran Q test and I2 statistics. A p-value of

Suggested Citation

  • Francisco Cezar Aquino de Moraes & Maria Eduarda Cavalcanti Souza & Lucca Dal Moro & Isabelle Batista Donadon & Emanuele Rocha da Silva & Dilma do Socorro Moraes de Souza & Rommel Mario Rodríguez Burb, 2024. "Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 18(9), pages 1-13, September.
    • Handle: RePEc:plo:pntd00:0012407
    DOI: 10.1371/journal.pntd.0012407
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012407
    Download Restriction: no
    File URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012407&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pntd.0012407?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pntd00:0012407. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosntds (email available below). General contact details of provider: https://journals.plos.org/plosntds/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.