The current and future distribution of the yellow fever mosquito (Aedes aegypti) on Madeira Island

The Aedes aegypti mosquito is the main vector for several diseases of global importance, such as dengue and yellow fever. This species was first identified on Madeira Island in 2005, and between 2012 and 2013 was responsible for an outbreak of dengue that affected several thousand people. However, the potential distribution of the species on the island remains poorly investigated. Here we assess the suitability of current and future climatic conditions to the species on the island and complement this assessment with estimates of the suitability of land use and human settlement conditions. We used four modelling algorithms (boosted regression trees, generalized additive models, generalized linear models and random forest) and data on the distribution of the species worldwide and across the island. For both climatic and non-climatic factors, suitability estimates predicted the current distribution of the species with good accuracy (mean area under the Receiver Operating Characteristic curve = 0.88 ±0.06, mean true skill statistic = 0.72 ±0.1). Minimum temperature of coldest month was the most influential climatic predictor, while human population density, residential housing density and public spaces were the most influential predictors describing land use and human settlement conditions. Suitable areas under current climates are predicted to occur mainly in the warmer and densely inhabited coastal areas of the southern part of the island, where the species is already established. By mid-century (2041–2060), the extent of climatically suitable areas is expected to increase, mainly towards higher altitudes and in the eastern part of the island. Our work shows that ongoing efforts to monitor and prevent the spread of Ae. aegypti on Madeira Island will have to increasingly consider the effects of climate change.Author summary: The Aedes aegypti mosquito is an invasive species on Madeira Island and recently responsible for a dengue outbreak that affected more than 2000 people. To help control the activity of this mosquito, the local health authorities have an entomological surveillance program in place throughout the island. However, the full extent of the areas that can be colonized by this species remains unknown. We estimate the current and future potential distribution of Ae. aegypti on Madeira Island accounting for climatic, land use and human settlement conditions. Our results suggest that suitable conditions are predominantly distributed along the southern coast of the island. However, as climate change progresses, climatically suitable areas are expected to increase, particularly at mid-altitudes and in eastern part of the island. Minimum temperature of the coldest month was the most influential predictor variable in climatic suitability models, while human population density, housing density and public spaces were the most influential in models of land use and human settlement suitability. Our work provides valuable insight on the potential distribution of Ae. aegypti on Madeira Island, which can be used to inform ongoing and future monitoring and prevention initiatives.