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Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium

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  • Jean T Coulibaly
  • Yve K N'Gbesso
  • Stefanie Knopp
  • Jennifer Keiser
  • Eliézer K N'Goran
  • Jürg Utzinger

Abstract

Background: In sub-Saharan Africa the recommended strategy to control schistosomiasis is preventive chemotherapy. Emphasis is placed on school-aged children, but in high endemicity areas, preschool-aged children are also at risk, and hence might need treatment with praziquantel. Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied. Methodology: We assessed the efficacy and safety of crushed praziquantel tablets among preschool-aged children (

Suggested Citation

  • Jean T Coulibaly & Yve K N'Gbesso & Stefanie Knopp & Jennifer Keiser & Eliézer K N'Goran & Jürg Utzinger, 2012. "Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 6(12), pages 1-9, December.
    • Handle: RePEc:plo:pntd00:0001917
    DOI: 10.1371/journal.pntd.0001917
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