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UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia

Author

Listed:
  • Arushika Aggarwal
  • Simon Erridge
  • Isaac Cowley
  • Lilia Evans
  • Madhur Varadpande
  • Evonne Clarke
  • Katy McLachlan
  • Ross Coomber
  • James J Rucker
  • Mark W Weatherall
  • Mikael H Sodergren

Abstract

Insomnia affects approximately 10% of adults globally. Current treatments have their limitations, and there is growing evidence on the therapeutic potential of cannabis-based medicinal products for insomnia. This study aimed to assess changes in sleep-specific and general patient-reported outcome measures (PROMs) in individuals prescribed cannabis-based medicinal products for insomnia and to assess the incidence of adverse events. A case series was analysed with patients diagnosed with primary insomnia from the UK Medical Cannabis Registry (UKMCR). The primary outcome examined changes in the Single-Item Sleep Quality Scale (SQS), Generalised Anxiety Disorder-7 (GAD-7), and EuroQol-5 Dimension-5 Level (EQ-5D-5L). Changes in PROMs were assessed from baseline to 1-, 3-, 6-, 12- and 18-months. Adverse events were classified according to the CTCAE version 4.0. The inclusion criteria were met by 124 participants. SQS scores showed improvement from baseline (2.66 ± 2.41) to 1- (5.67 ± 2.65; p

Suggested Citation

  • Arushika Aggarwal & Simon Erridge & Isaac Cowley & Lilia Evans & Madhur Varadpande & Evonne Clarke & Katy McLachlan & Ross Coomber & James J Rucker & Mark W Weatherall & Mikael H Sodergren, 2025. "UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia," PLOS Mental Health, Public Library of Science, vol. 2(8), pages 1-22, August.
    • Handle: RePEc:plo:pmen00:0000390
    DOI: 10.1371/journal.pmen.0000390
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