IDEAS home Printed from https://ideas.repec.org/a/plo/pmed00/1004298.html
   My bibliography  Save this article

Screening uptake of colonoscopy versus fecal immunochemical testing in first-degree relatives of patients with non-syndromic colorectal cancer: A multicenter, open-label, parallel-group, randomized trial (ParCoFit study)

Author

Listed:
  • Natalia González-López
  • Enrique Quintero
  • Antonio Z Gimeno-Garcia
  • Luis Bujanda
  • Jesús Banales
  • Joaquin Cubiella
  • María Salve-Bouzo
  • Jesus Miguel Herrero-Rivas
  • Estela Cid-Delgado
  • Victoria Alvarez-Sanchez
  • Alejandro Ledo-Rodríguez
  • Maria Luisa de-Castro-Parga
  • Romina Fernández-Poceiro
  • Luciano Sanromán-Álvarez
  • Jose Santiago-Garcia
  • Alberto Herreros-de-Tejada
  • Teresa Ocaña-Bombardo
  • Francesc Balaguer
  • María Rodríguez-Soler
  • Rodrigo Jover
  • Marta Ponce
  • Cristina Alvarez-Urturi
  • Xavier Bessa
  • Maria-Pilar Roncales
  • Federico Sopeña
  • Angel Lanas
  • David Nicolás-Pérez
  • Zaida Adrián-de-Ganzo
  • Marta Carrillo-Palau
  • Enrique González-Dávila
  • On behalf of the Oncology Group of Asociación Española de Gastroenterología

Abstract

Background: Colonoscopy screening is underused by first-degree relatives (FDRs) of patients with non-syndromic colorectal cancer (CRC) with screening completion rates below 50%. Studies conducted in FDR referred for screening suggest that fecal immunochemical testing (FIT) was not inferior to colonoscopy in terms of diagnostic yield and tumor staging, but screening uptake of FIT has not yet been tested in this population. In this study, we investigated whether the uptake of FIT screening is superior to the uptake of colonoscopy screening in the familial-risk population, with an equivalent effect on CRC detection. Methods and findings: This open-label, parallel-group, randomized trial was conducted in 12 Spanish centers between February 2016 and December 2021. Eligible individuals included asymptomatic FDR of index cases

Suggested Citation

  • Natalia González-López & Enrique Quintero & Antonio Z Gimeno-Garcia & Luis Bujanda & Jesús Banales & Joaquin Cubiella & María Salve-Bouzo & Jesus Miguel Herrero-Rivas & Estela Cid-Delgado & Victoria A, 2023. "Screening uptake of colonoscopy versus fecal immunochemical testing in first-degree relatives of patients with non-syndromic colorectal cancer: A multicenter, open-label, parallel-group, randomized tr," PLOS Medicine, Public Library of Science, vol. 20(10), pages 1-21, October.
    • Handle: RePEc:plo:pmed00:1004298
    DOI: 10.1371/journal.pmed.1004298
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004298
    Download Restriction: no
    File URL: https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004298&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pmed.1004298?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pmed00:1004298. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosmedicine (email available below). General contact details of provider: https://journals.plos.org/plosmedicine/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.