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Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: A systematic review and meta-analysis

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  • Francesco D’Antonio
  • Nashwa Eltaweel
  • Smriti Prasad
  • Maria Elena Flacco
  • Lamberto Manzoli
  • Asma Khalil

Abstract

Background: The optimal approach to prevent preterm birth (PTB) in twins has not been fully established yet. Recent evidence suggests that placement of cervical cerclage in twin pregnancies with short cervical length at ultrasound or cervical dilatation at physical examination might be associated with a reduced risk of PTB. However, such evidence is based mainly on small studies thus questioning the robustness of these findings. The aim of this systematic review was to determine the role of cervical cerclage in preventing PTB and adverse maternal or perinatal outcomes in twin pregnancies. Methods and findings: Key databases searched and date of last search: MEDLINE, Embase, and CINAHL were searched electronically on 20 April 2023. Conclusions: Emergency cerclage for cervical dilation or short cervical length

Suggested Citation

  • Francesco D’Antonio & Nashwa Eltaweel & Smriti Prasad & Maria Elena Flacco & Lamberto Manzoli & Asma Khalil, 2023. "Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: A systematic review and meta-analysis," PLOS Medicine, Public Library of Science, vol. 20(8), pages 1-24, August.
    • Handle: RePEc:plo:pmed00:1004266
    DOI: 10.1371/journal.pmed.1004266
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