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Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data linkage study

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  • Laurentya Olga
  • Ulla Sovio
  • Hilary Wong
  • Gordon Smith
  • Catherine Aiken

Abstract

Background: Fetal growth restriction (FGR) is associated with a suboptimal intrauterine environment, which may adversely impact fetal neurodevelopment. However, analysing neurodevelopmental outcomes by observed birthweight fails to differentiate between true FGR and constitutionally small infants and cannot account for iatrogenic intervention. This study aimed to determine the relationship between antenatal FGR and mid-childhood (age 5 to 7 years) educational outcomes. Methods and findings: The Pregnancy Outcome Prediction Study (2008–2012) was a prospective birth cohort conducted in a single maternity hospital in Cambridge, United Kingdom. Clinicians were blinded to the antenatal diagnosis of FGR. FGR was defined as estimated fetal weight (EFW)

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  • Laurentya Olga & Ulla Sovio & Hilary Wong & Gordon Smith & Catherine Aiken, 2023. "Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data linkage study," PLOS Medicine, Public Library of Science, vol. 20(4), pages 1-17, April.
    • Handle: RePEc:plo:pmed00:1004225
    DOI: 10.1371/journal.pmed.1004225
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