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Cervical intraepithelial neoplasia and the risk of spontaneous preterm birth: A Dutch population-based cohort study with 45,259 pregnancy outcomes

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  • Diede L Loopik
  • Joris van Drongelen
  • Ruud L M Bekkers
  • Quirinus J M Voorham
  • Willem J G Melchers
  • Leon F A G Massuger
  • Folkert J van Kemenade
  • Albert G Siebers

Abstract

Background: Excisional procedures of cervical intraepithelial neoplasia (CIN) may increase the risk of preterm birth. It is unknown whether this increased risk is due to the excision procedure itself, to the underlying CIN, or to secondary risk factors that are associated with both preterm birth and CIN. The aim of this study is to assess the risk of spontaneous preterm birth in women with treated and untreated CIN and examine possible associations by making a distinction between the excised volume of cervical tissue and having cervical disease. Methods and findings: This Dutch population-based observational cohort study identified women aged 29 to 41 years with CIN between 2005 and 2015 from the Dutch pathology registry (PALGA) and frequency matched them with a control group without any cervical abnormality based on age at and year of pathology outcome (i.e., CIN or normal cytology) and urbanization (

Suggested Citation

  • Diede L Loopik & Joris van Drongelen & Ruud L M Bekkers & Quirinus J M Voorham & Willem J G Melchers & Leon F A G Massuger & Folkert J van Kemenade & Albert G Siebers, 2021. "Cervical intraepithelial neoplasia and the risk of spontaneous preterm birth: A Dutch population-based cohort study with 45,259 pregnancy outcomes," PLOS Medicine, Public Library of Science, vol. 18(6), pages 1-20, June.
    • Handle: RePEc:plo:pmed00:1003665
    DOI: 10.1371/journal.pmed.1003665
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