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Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

Author

Listed:
  • Giovanni Musso
  • Roberto Gambino
  • James H Tabibian
  • Mattias Ekstedt
  • Stergios Kechagias
  • Masahide Hamaguchi
  • Rolf Hultcrantz
  • Hannes Hagström
  • Seung Kew Yoon
  • Phunchai Charatcharoenwitthaya
  • Jacob George
  • Francisco Barrera
  • Svanhildur Hafliðadóttir
  • Einar Stefan Björnsson
  • Matthew J Armstrong
  • Laurence J Hopkins
  • Xin Gao
  • Sven Francque
  • An Verrijken
  • Yusuf Yilmaz
  • Keith D Lindor
  • Michael Charlton
  • Robin Haring
  • Markus M Lerch
  • Rainer Rettig
  • Henry Völzke
  • Seungho Ryu
  • Guolin Li
  • Linda L Wong
  • Mariana Machado
  • Helena Cortez-Pinto
  • Kohichiroh Yasui
  • Maurizio Cassader

Abstract

: In a systematic review and meta-analysis, Giovanni Musso and colleagues examine the association between non-alcoholic fatty liver disease and chronic kidney disease. Background: Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associated with the presence and severity of CKD. Methods and Findings: English and non-English articles from international online databases from 1980 through January 31, 2014 were searched. Observational studies assessing NAFLD by histology, imaging, or biochemistry and defining CKD as either estimated glomerular filtration rate (eGFR)

Suggested Citation

  • Giovanni Musso & Roberto Gambino & James H Tabibian & Mattias Ekstedt & Stergios Kechagias & Masahide Hamaguchi & Rolf Hultcrantz & Hannes Hagström & Seung Kew Yoon & Phunchai Charatcharoenwitthaya & , 2014. "Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis," PLOS Medicine, Public Library of Science, vol. 11(7), pages 1-26, July.
    • Handle: RePEc:plo:pmed00:1001680
    DOI: 10.1371/journal.pmed.1001680
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