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Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

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  • Bertran Auvert
  • Dirk Taljaard
  • Emmanuel Lagarde
  • Joëlle Sobngwi-Tambekou
  • Rémi Sitta
  • Adrian Puren

Abstract

Background: Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. Methods and Findings: A total of 3,274 uncircumcised men, aged 18–24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the intervention group immediately after randomization and to the control group at the end of the follow-up. The grouped censored data were analyzed in intention-to-treat, univariate and multivariate, analyses, using piecewise exponential, proportional hazards models. Rate ratios (RR) of HIV incidence were determined with 95% CI. Protection against HIV infection was calculated as 1 − RR. The trial was stopped at the interim analysis, and the mean (interquartile range) follow-up was 18.1 mo (13.0–21.0) when the data were analyzed. There were 20 HIV infections (incidence rate = 0.85 per 100 person-years) in the intervention group and 49 (2.1 per 100 person-years) in the control group, corresponding to an RR of 0.40 (95% CI: 0.24%–0.68%; p

Suggested Citation

  • Bertran Auvert & Dirk Taljaard & Emmanuel Lagarde & Joëlle Sobngwi-Tambekou & Rémi Sitta & Adrian Puren, 2005. "Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial," PLOS Medicine, Public Library of Science, vol. 2(11), pages 1-1, October.
    • Handle: RePEc:plo:pmed00:0020298
    DOI: 10.1371/journal.pmed.0020298
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