IDEAS home Printed from https://ideas.repec.org/a/plo/pgph00/0003638.html
   My bibliography  Save this article

Cost-effectiveness of diagnostic technologies for mycobacterium tuberculosis infection in India and Brazil

Author

Listed:
  • Saima Bashir
  • Shehzad Ali
  • Seda Yerlikaya
  • Mary Gaeddert
  • Lara Goscé
  • Molebogeng X Rangaka
  • Claudia M. Denkinger

Abstract

The economic value of new skin-based tests and blood-based interferon-γ release assays (IGRAs) for tuberculosis (TB) infection is not yet well-established. This study evaluates the cost and cost-effectiveness in two high-burden countries by comparing:(a) new skin-based tests(Diaskintest and Cy-Tb) with the purified protein derivative (PPD)-tuberculin test (TST);(b) IGRAs (Standard E TB-Feron ELISA (TBF))with approved IGRAs (QuantiFERON-TB Gold Plus (QFT-GP)and TSPOT.TB); and (c) the best performing skin-based test with the best performing IGRA) based on cost effectiveness. In this paper, we developed a decision tree model for India and Brazil from a health system perspective. To quantify the effect of parameter variability and uncertainty, we performed both univariate and probabilistic sensitivity analysis. The study findings reveal that among skin-based tests, the Diaskintest is more cost-effective compared to TST-PPD at 22.6 USD and 41.0 USD per correctly diagnosed case of TB infection for Brazil and India, respectively. For blood-based assays, TSPOT.TB outperforms QFT-GP and TBF due to its lower cost and higher effectiveness. When compared with Diaskintest, TSPOT.TB has an incremental cost of approximately 8 USD and 6 USD for India and Brazil respectively but is more effective. The incremental cost-effectiveness ratio (ICER) was 74 USD and 55 USD for India and Brazil, respectively. In summary, while Diaskintest is potentially cost-saving when compared to TSPOT.TB in these two high-burden TB countries but the TSPOT.TB demonstrates higher effectiveness.

Suggested Citation

  • Saima Bashir & Shehzad Ali & Seda Yerlikaya & Mary Gaeddert & Lara Goscé & Molebogeng X Rangaka & Claudia M. Denkinger, 2024. "Cost-effectiveness of diagnostic technologies for mycobacterium tuberculosis infection in India and Brazil," PLOS Global Public Health, Public Library of Science, vol. 4(11), pages 1-15, November.
    • Handle: RePEc:plo:pgph00:0003638
    DOI: 10.1371/journal.pgph.0003638
    as

    Download full text from publisher

    File URL: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0003638
    Download Restriction: no
    File URL: https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0003638&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pgph.0003638?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lara Goscé & Kasim Allel & Yohhei Hamada & Alexei Korobitsyn & Nazir Ismail & Saima Bashir & Claudia M Denkinger & Ibrahim Abubakar & Peter J White & Molebogeng X Rangaka, 2023. "Economic evaluation of novel Mycobacterium tuberculosis specific antigen-based skin tests for detection of TB infection: A modelling study," PLOS Global Public Health, Public Library of Science, vol. 3(12), pages 1-13, December.
    2. Rafaela Borge Loureiro & Ethel Leonor Noia Maciel & Rosangela Caetano & Renata Lyrio Peres & Geisa Fregona & Jonathan E Golub & José Ueleres Braga, 2019. "Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-24, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lara Goscé & Kasim Allel & Yohhei Hamada & Alexei Korobitsyn & Nazir Ismail & Saima Bashir & Claudia M Denkinger & Ibrahim Abubakar & Peter J White & Molebogeng X Rangaka, 2023. "Economic evaluation of novel Mycobacterium tuberculosis specific antigen-based skin tests for detection of TB infection: A modelling study," PLOS Global Public Health, Public Library of Science, vol. 3(12), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pgph00:0003638. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: globalpubhealth (email available below). General contact details of provider: https://journals.plos.org/globalpublichealth .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.