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Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries

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  • Neil Parkin
  • P Richard Harrigan
  • Seth Inzaule
  • Silvia Bertagnolio

Abstract

Resistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and transmission of resistance over the past decade have shown that drug resistance–especially to the nucleoside analogue and non-nucleoside reverse transcriptase inhibitors–can (and have) increased to levels that can jeopardize the efficacy of available treatment options at the population level. The global shift to integrase-based regimens as the preferred first-line therapy as well as technological advancements in the methods for detecting resistance have had an impact in broadening and diversifying the landscape of and use case for HIV drug resistance testing. This review estimates the potential demand for HIV drug resistance tests, and surveys current testing methodologies, with a focus on their application in LMICs.

Suggested Citation

  • Neil Parkin & P Richard Harrigan & Seth Inzaule & Silvia Bertagnolio, 2023. "Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries," PLOS Global Public Health, Public Library of Science, vol. 3(10), pages 1-19, October.
    • Handle: RePEc:plo:pgph00:0001948
    DOI: 10.1371/journal.pgph.0001948
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    1. Soo-Yon Rhee & Michael R Jordan & Elliot Raizes & Arlene Chua & Neil Parkin & Rami Kantor & Gert U Van Zyl & Irene Mukui & Mina C Hosseinipour & Lisa M Frenkel & Nicaise Ndembi & Raph L Hamers & Tobia, 2015. "HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-17, December.
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