IDEAS home Printed from https://ideas.repec.org/a/plo/pgph00/0000826.html
   My bibliography  Save this article

HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: A systematic review and meta-analysis

Author

Listed:
  • Ezechiel Ngoufack Jagni Semengue
  • Maria Mercedes Santoro
  • Valantine Ngum Ndze
  • Aude Christelle Ka’e
  • Bouba Yagai
  • Alex Durand Nka
  • Beatrice Dambaya
  • Desiré Takou
  • Georges Teto
  • Lavinia Fabeni
  • Vittorio Colizzi
  • Carlo-Federico Perno
  • Francesca Ceccherini-Silberstein
  • Joseph Fokam

Abstract

As sub-Saharan Africa (SSA) countries are transitioning to dolutegravir (DTG)-based ART, baseline data are required for optimal monitoring of therapeutic response. In this frame, we sought to generate up-to-date evidence on the use of integrase-strand transfer inhibitors (INSTI) and associated drug resistance mutations (DRMs) within SSA. In this systematic review and meta-analysis, we included randomized and non-randomized trials, cohort-studies, cross-sectional studies, and case-reports published on INSTI or integrase DRMs in SSA. We included studies of patients exposed to DTG, raltegravir (RAL) or elvitegravir (EVG). Primary outcomes were “the rate of virological control (VC:

Suggested Citation

  • Ezechiel Ngoufack Jagni Semengue & Maria Mercedes Santoro & Valantine Ngum Ndze & Aude Christelle Ka’e & Bouba Yagai & Alex Durand Nka & Beatrice Dambaya & Desiré Takou & Georges Teto & Lavinia Fabeni, 2022. "HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: A systematic review and meta-analysis," PLOS Global Public Health, Public Library of Science, vol. 2(10), pages 1-19, October.
    • Handle: RePEc:plo:pgph00:0000826
    DOI: 10.1371/journal.pgph.0000826
    as

    Download full text from publisher

    File URL: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000826
    Download Restriction: no
    File URL: https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0000826&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pgph.0000826?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mark J. Siedner & Michelle A. Moorhouse & Bryony Simmons & Tulio Oliveira & Richard Lessells & Jennifer Giandhari & Stephen A. Kemp & Benjamin Chimukangara & Godspower Akpomiemie & Celicia M. Serenata, 2020. "Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. repec:plo:pmed00:1002706 is not listed on IDEAS
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Steven A. Kemp & Kimia Kamelian & Diego F. Cuadros & Mark T. K. Cheng & Elphas Okango & Willem Hanekom & Thumbi Ndung’u & Deenan Pillay & David Bonsall & Emily B. Wong & Frank Tanser & Mark J. Siedner, 2024. "HIV transmission dynamics and population-wide drug resistance in rural South Africa," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pgph00:0000826. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: globalpubhealth (email available below). General contact details of provider: https://journals.plos.org/globalpublichealth .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.