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Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort

Author

Listed:
  • Xiya Song
  • Han Jin
  • Xiangyu Li
  • Meng Yuan
  • Hong Yang
  • Yusuke Sato
  • Haruki Kume
  • Seishi Ogawa
  • Cheng Zhang
  • Adil Mardinoglu

Abstract

Background: Clear cell renal carcinoma (ccRCC) is the predominant form of kidney cancer, but the prognostic value of expression quantitative trait loci (eQTLs) remains underexplored, particularly in Asian populations. Objective: We analyzed whole-exome sequencing and RNA sequencing data from 100 Japanese ccRCC patients to identify eQTLs. Multiple Cox proportional hazard models assessed survival associations, with validation in the Cancer Genome Atlas ccRCC cohort (n = 287). Results: We identified 805 eGenes and 4,558 cis-eQTLs in the Japanese cohort. Survival analysis revealed a total of 9 eGenes significantly associated with overall survival (FDR

Suggested Citation

  • Xiya Song & Han Jin & Xiangyu Li & Meng Yuan & Hong Yang & Yusuke Sato & Haruki Kume & Seishi Ogawa & Cheng Zhang & Adil Mardinoglu, 2025. "Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort," PLOS Genetics, Public Library of Science, vol. 21(7), pages 1-28, July.
    • Handle: RePEc:plo:pgen00:1011770
    DOI: 10.1371/journal.pgen.1011770
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    1. Kate Lawrenson & Qiyuan Li & Siddhartha Kar & Ji-Heui Seo & Jonathan Tyrer & Tassja J. Spindler & Janet Lee & Yibu Chen & Alison Karst & Ronny Drapkin & Katja K. H. Aben & Hoda Anton-Culver & Natalia , 2015. "Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer," Nature Communications, Nature, vol. 6(1), pages 1-14, November.
    2. Ghislaine Scelo & Mark P. Purdue & Kevin M. Brown & Mattias Johansson & Zhaoming Wang & Jeanette E. Eckel-Passow & Yuanqing Ye & Jonathan N. Hofmann & Jiyeon Choi & Matthieu Foll & Valerie Gaborieau &, 2017. "Genome-wide association study identifies multiple risk loci for renal cell carcinoma," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
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