IDEAS home Printed from https://ideas.repec.org/a/plo/pgen00/1005204.html
   My bibliography  Save this article

Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes

Author

Listed:
  • Yann C Klimentidis
  • Akshay Chougule
  • Amit Arora
  • Alexis C Frazier-Wood
  • Chiu-Hsieh Hsu

Abstract

Elevated plasma triglyceride (TG) levels are an established risk factor for type-2 diabetes (T2D). However, recent studies have hinted at the possibility that genetic risk for TG may paradoxically protect against T2D. In this study, we examined the association of genetic risk for TG with incident T2D, and the interaction of baseline TG with TG genetic risk on incident T2D in 13,247 European-Americans (EA) and 3,238 African-Americans (AA) from three prospective cohort studies. A TG genetic risk score (GRS) was calculated based on 31 validated single nucleotide polymorphisms (SNPs). We considered several baseline covariates, including body- mass index (BMI) and lipid traits. Among EA and AA, we find, as expected, that baseline levels of TG are strongly positively associated with incident T2D (p

Suggested Citation

  • Yann C Klimentidis & Akshay Chougule & Amit Arora & Alexis C Frazier-Wood & Chiu-Hsieh Hsu, 2015. "Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes," PLOS Genetics, Public Library of Science, vol. 11(5), pages 1-12, May.
  • Handle: RePEc:plo:pgen00:1005204
    DOI: 10.1371/journal.pgen.1005204
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005204
    Download Restriction: no

    File URL: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005204&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pgen.1005204?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pgen00:1005204. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosgenetics (email available below). General contact details of provider: https://journals.plos.org/plosgenetics/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.