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Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Author

Listed:
  • Ching-Ti Liu
  • Keri L Monda
  • Kira C Taylor
  • Leslie Lange
  • Ellen W Demerath
  • Walter Palmas
  • Mary K Wojczynski
  • Jaclyn C Ellis
  • Mara Z Vitolins
  • Simin Liu
  • George J Papanicolaou
  • Marguerite R Irvin
  • Luting Xue
  • Paula J Griffin
  • Michael A Nalls
  • Adebowale Adeyemo
  • Jiankang Liu
  • Guo Li
  • Edward A Ruiz-Narvaez
  • Wei-Min Chen
  • Fang Chen
  • Brian E Henderson
  • Robert C Millikan
  • Christine B Ambrosone
  • Sara S Strom
  • Xiuqing Guo
  • Jeanette S Andrews
  • Yan V Sun
  • Thomas H Mosley
  • Lisa R Yanek
  • Daniel Shriner
  • Talin Haritunians
  • Jerome I Rotter
  • Elizabeth K Speliotes
  • Megan Smith
  • Lynn Rosenberg
  • Josyf Mychaleckyj
  • Uma Nayak
  • Ida Spruill
  • W Timothy Garvey
  • Curtis Pettaway
  • Sarah Nyante
  • Elisa V Bandera
  • Angela F Britton
  • Alan B Zonderman
  • Laura J Rasmussen-Torvik
  • Yii-Der Ida Chen
  • Jingzhong Ding
  • Kurt Lohman
  • Stephen B Kritchevsky
  • Wei Zhao
  • Patricia A Peyser
  • Sharon L R Kardia
  • Edmond Kabagambe
  • Ulrich Broeckel
  • Guanjie Chen
  • Jie Zhou
  • Sylvia Wassertheil-Smoller
  • Marian L Neuhouser
  • Evadnie Rampersaud
  • Bruce Psaty
  • Charles Kooperberg
  • JoAnn E Manson
  • Lewis H Kuller
  • Heather M Ochs-Balcom
  • Karen C Johnson
  • Lara Sucheston
  • Jose M Ordovas
  • Julie R Palmer
  • Christopher A Haiman
  • Barbara McKnight
  • Barbara V Howard
  • Diane M Becker
  • Lawrence F Bielak
  • Yongmei Liu
  • Matthew A Allison
  • Struan F A Grant
  • Gregory L Burke
  • Sanjay R Patel
  • Pamela J Schreiner
  • Ingrid B Borecki
  • Michele K Evans
  • Herman Taylor
  • Michele M Sale
  • Virginia Howard
  • Christopher S Carlson
  • Charles N Rotimi
  • Mary Cushman
  • Tamara B Harris
  • Alexander P Reiner
  • L Adrienne Cupples
  • Kari E North
  • Caroline S Fox

Abstract

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values

Suggested Citation

  • Ching-Ti Liu & Keri L Monda & Kira C Taylor & Leslie Lange & Ellen W Demerath & Walter Palmas & Mary K Wojczynski & Jaclyn C Ellis & Mara Z Vitolins & Simin Liu & George J Papanicolaou & Marguerite R , 2013. "Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci," PLOS Genetics, Public Library of Science, vol. 9(8), pages 1-16, August.
    • Handle: RePEc:plo:pgen00:1003681
    DOI: 10.1371/journal.pgen.1003681
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    Cited by:

    1. Raphael D. Isokpehi & Shaneka S. Simmons & Matilda O. Johnson & Marinelle Payton, 2017. "Genomic Evidence for Bacterial Determinants Influencing Obesity Development," IJERPH, MDPI, vol. 14(4), pages 1-11, March.

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