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A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

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  • International Parkinson's Disease Genomics Consortium (IPDGC)
  • Wellcome Trust Case Control Consortium 2 (WTCCC2)

Abstract

A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p

Suggested Citation

  • International Parkinson's Disease Genomics Consortium (IPDGC) & Wellcome Trust Case Control Consortium 2 (WTCCC2), 2011. "A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease," PLOS Genetics, Public Library of Science, vol. 7(6), pages 1-9, June.
    • Handle: RePEc:plo:pgen00:1002142
    DOI: 10.1371/journal.pgen.1002142
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    1. Tohru Kitada & Shuichi Asakawa & Nobutaka Hattori & Hiroto Matsumine & Yasuhiro Yamamura & Shinsei Minoshima & Masayuki Yokochi & Yoshikuni Mizuno & Nobuyoshi Shimizu, 1998. "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism," Nature, Nature, vol. 392(6676), pages 605-608, April.
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