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Synthesis and Antibacterial Activity of Some Novel N,N-Di-Oxalamide Derivatives

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  • Maha Habash
  • Mohammad Yasin Mohammad
  • Manal Ayyash
  • Mutasem O Taha

Abstract

Novel N,N-di-oxalamide derivatives 1-6 were synthesized and characterized by the spectroscopic techniques. These derivatives showed good antibacterial activities against Gram-negative organism Escherichia coli and Gram-positive organisms Staphylococcus aureus and Bacillus subtilus. However, compounds 3 and 4 showed potent antibacterial activity against Gram-negative organism Escherichia coliand Gram-positive organism Staphylococcus aureus. In addition to that, we compared their antibacterial profiles with previously synthesized N,N-di-oxalamide derivatives 7-9. The new compounds showed superior antibacterial activities compared to moderate activities for 7-9.

Suggested Citation

  • Maha Habash & Mohammad Yasin Mohammad & Manal Ayyash & Mutasem O Taha, 2015. "Synthesis and Antibacterial Activity of Some Novel N,N-Di-Oxalamide Derivatives," International Journal of Chemistry and Materials Research, Conscientia Beam, vol. 3(12), pages 165-175.
    • Handle: RePEc:pkp:ijocmr:v:3:y:2015:i:12:p:165-175:id:1864
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