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Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety

Author

Listed:
  • A.A Elhenawy
  • M. A El-Gazzar
  • H. M Mohmoud
  • W. I El-Eraky
  • S.A. W El-Awdan

Abstract

The present work aims to synthesize novel diclofenac derivatives containing L-leucine moiety. The synthesized compounds docked into the active site to discover validated inhibitors of cyclooxygenases (COX-1 and COX-2). The calculations in-silico were predicted that, the compound with lowest energy of docked poses was interacted with residues of active site, perhaps could be making them possible selective inhibitors against (COX-2) and physiologically active. The binding score of compound compared with reference drug, and show extensive interactions with the targets, which may consider it a suitable selective inhibitor against (COX-2).

Suggested Citation

  • A.A Elhenawy & M. A El-Gazzar & H. M Mohmoud & W. I El-Eraky & S.A. W El-Awdan, 2013. "Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety," International Journal of Chemistry and Materials Research, Conscientia Beam, vol. 1(1), pages 1-13.
    • Handle: RePEc:pkp:ijocmr:v:1:y:2013:i:1:p:1-13:id:1823
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    Keywords

    Leucine; Diclofenac; Cox; Docking; Admet;
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