IDEAS home Printed from https://ideas.repec.org/a/pkp/ijcper/v1y2014i6p109-120id1799.html
   My bibliography  Save this article

Synthesis, Physico-Chemical and Antimicrobial Properties of Some Metal (II) -Mixed Ligand Complexes of Tridentate Schiff Base Derives From Β-Lactam Antibiotic {(Cephalexin Mono Hydrate)-4-Chlorobenzophenone} and Saccharin

Author

Listed:
  • Taghreed H Al-Noor
  • Amer J Jarad
  • Abaas Obaid Hussein

Abstract

A new Schiff base (4-chlorophenyl)(phenyl methanimine (6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate=HL=C29H24ClN3O4S) has been synthesized from β-lactam antibiotic (cephalexin mono hydrate (CephH)=(C16H19N3O5S.H2O) and 4- chlorobenzophenone. Metal mixed ligand complexes of the Schiff base were prepared from chloride salt of Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), in 50% (v/v) ethanol – water medium in aqueous ethanol(1:1) and Saccharin(C7H5NO3S) containing sodium hydroxide. Several physical tools in particular; IR, C:H:N , 1H NMR,13C NMR for ligand, melting point, molar conductance, magnetic moment. and determination of the percentage of the metal in the complexes by flame(AAS). The ligand and their metal complexes were screened for their antimicrobial activity against four bacteria (gram +ve) and (gram -ve) [Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus]. The proposed structure of the complexes using the program, Chem office 3D (2006) and the general formula have been given for the prepared mixed ligand complexes [M(Sac)3(L)].

Suggested Citation

  • Taghreed H Al-Noor & Amer J Jarad & Abaas Obaid Hussein, 2014. "Synthesis, Physico-Chemical and Antimicrobial Properties of Some Metal (II) -Mixed Ligand Complexes of Tridentate Schiff Base Derives From Β-Lactam Antibiotic {(Cephalexin Mono Hydrate)-4-Chlorobenzop," International Journal of Chemical and Process Engineering Research, Conscientia Beam, vol. 1(6), pages 109-120.
    • Handle: RePEc:pkp:ijcper:v:1:y:2014:i:6:p:109-120:id:1799
    as

    Download full text from publisher

    File URL: https://archive.conscientiabeam.com/index.php/65/article/view/1799/2507
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:pkp:ijcper:v:1:y:2014:i:6:p:109-120:id:1799. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Dim Michael (email available below). General contact details of provider: https://archive.conscientiabeam.com/index.php/65/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.