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Analysing panel count data with informative observation times

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  • Chiung-Yu Huang
  • Mei-Cheng Wang
  • Ying Zhang

Abstract

In this paper, we study panel count data with informative observation times. We assume nonparametric and semiparametric proportional rate models for the underlying event process, where the form of the baseline rate function is left unspecified and a subject-specific frailty variable inflates or deflates the rate function multiplicatively. The proposed models allow the event processes and observation times to be correlated through their connections with the unobserved frailty; moreover, the distributions of both the frailty variable and observation times are considered as nuisance parameters. The baseline rate function and the regression parameters are estimated by maximising a conditional likelihood function of observed event counts and solving estimation equations. Large-sample properties of the proposed estimators are studied. Numerical studies demonstrate that the proposed estimation procedures perform well for moderate sample sizes. An application to a bladder tumour study is presented. Copyright 2006, Oxford University Press.

Suggested Citation

  • Chiung-Yu Huang & Mei-Cheng Wang & Ying Zhang, 2006. "Analysing panel count data with informative observation times," Biometrika, Biometrika Trust, vol. 93(4), pages 763-775, December.
  • Handle: RePEc:oup:biomet:v:93:y:2006:i:4:p:763-775
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    File URL: http://hdl.handle.net/10.1093/biomet/93.4.763
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    References listed on IDEAS

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    1. Joseph P. Romano & Michael Wolf, 2005. "Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 94-108, March.
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    Cited by:

    1. Li, Yang & Zhao, Hui & Sun, Jianguo & Kim, KyungMann, 2014. "Nonparametric tests for panel count data with unequal observation processes," Computational Statistics & Data Analysis, Elsevier, vol. 73(C), pages 103-111.
    2. repec:spr:lifeda:v:23:y:2017:i:3:d:10.1007_s10985-016-9368-x is not listed on IDEAS
    3. Xingwei Tong, 2011. "Comments on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 58-61, May.
    4. Xin He & Xuenan Feng & Xingwei Tong & Xingqiu Zhao, 0. "Semiparametric partially linear varying coefficient models with panel count data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 0, pages 1-28.
    5. Xingqiu Zhao & N. Balakrishnan & Jianguo Sun, 2011. "Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 1-42, May.
    6. Zhao, Xingqiu & Tong, Xingwei, 2011. "Semiparametric regression analysis of panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 291-300, January.
    7. Xingqiu Zhao & N. Balakrishnan & Jianguo Sun, 2011. "Rejoinder on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 65-71, May.
    8. Zhao, Xingqiu & Tong, Xingwei & Sun, Jianguo, 2013. "Robust estimation for panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 33-40.
    9. Zhang, Haixiang & Zhao, Hui & Sun, Jianguo & Wang, Dehui & Kim, KyungMann, 2013. "Regression analysis of multivariate panel count data with an informative observation process," Journal of Multivariate Analysis, Elsevier, vol. 119(C), pages 71-80.
    10. Yang Li & Xin He & Haiying Wang & Jianguo Sun, 2016. "Regression analysis of longitudinal data with correlated censoring and observation times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 22(3), pages 343-362, July.
    11. Jacobo Uña-Álvarez, 2011. "Comments on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 62-64, May.
    12. repec:spr:lifeda:v:23:y:2017:i:4:d:10.1007_s10985-016-9375-y is not listed on IDEAS
    13. Jie Zhou & Haixiang Zhang & Liuquan Sun & Jianguo Sun, 0. "Joint analysis of panel count data with an informative observation process and a dependent terminal event," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 0, pages 1-25.

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