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Analysing panel count data with informative observation times

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  • Chiung-Yu Huang
  • Mei-Cheng Wang
  • Ying Zhang

Abstract

In this paper, we study panel count data with informative observation times. We assume nonparametric and semiparametric proportional rate models for the underlying event process, where the form of the baseline rate function is left unspecified and a subject-specific frailty variable inflates or deflates the rate function multiplicatively. The proposed models allow the event processes and observation times to be correlated through their connections with the unobserved frailty; moreover, the distributions of both the frailty variable and observation times are considered as nuisance parameters. The baseline rate function and the regression parameters are estimated by maximising a conditional likelihood function of observed event counts and solving estimation equations. Large-sample properties of the proposed estimators are studied. Numerical studies demonstrate that the proposed estimation procedures perform well for moderate sample sizes. An application to a bladder tumour study is presented. Copyright 2006, Oxford University Press.

Suggested Citation

  • Chiung-Yu Huang & Mei-Cheng Wang & Ying Zhang, 2006. "Analysing panel count data with informative observation times," Biometrika, Biometrika Trust, vol. 93(4), pages 763-775, December.
    • Handle: RePEc:oup:biomet:v:93:y:2006:i:4:p:763-775
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    Cited by:

    1. Li, Yang & Zhao, Hui & Sun, Jianguo & Kim, KyungMann, 2014. "Nonparametric tests for panel count data with unequal observation processes," Computational Statistics & Data Analysis, Elsevier, vol. 73(C), pages 103-111.
    2. Na Cai & Wenbin Lu & Hao Helen Zhang, 2012. "Time-Varying Latent Effect Model for Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 68(4), pages 1093-1102, December.
    3. Li, Yang & He, Xin & Wang, Haiying & Zhang, Bin & Sun, Jianguo, 2015. "Semiparametric regression of multivariate panel count data with informative observation times," Journal of Multivariate Analysis, Elsevier, vol. 140(C), pages 209-219.
    4. Xin He & Xuenan Feng & Xingwei Tong & Xingqiu Zhao, 2017. "Semiparametric partially linear varying coefficient models with panel count data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(3), pages 439-466, July.
    5. Hangjin Jiang & Wen Su & Xingqiu Zhao, 2020. "Robust estimation for panel count data with informative observation times and censoring times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(1), pages 65-84, January.
    6. Xingqiu Zhao & N. Balakrishnan & Jianguo Sun, 2011. "Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 1-42, May.
    7. Xingqiu Zhao & N. Balakrishnan & Jianguo Sun, 2011. "Rejoinder on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 65-71, May.
    8. Yu Liang & Wenbin Lu & Zhiliang Ying, 2009. "Joint Modeling and Analysis of Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 65(2), pages 377-384, June.
    9. Sy Han Chiou & Gongjun Xu & Jun Yan & Chiung‐Yu Huang, 2018. "Semiparametric estimation of the accelerated mean model with panel count data under informative examination times," Biometrics, The International Biometric Society, vol. 74(3), pages 944-953, September.
    10. Jacobo Uña-Álvarez, 2011. "Comments on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 62-64, May.
    11. P. G. Sankaran & P. Anisha, 2011. "Shared frailty model for recurrent event data with multiple causes," Journal of Applied Statistics, Taylor & Francis Journals, vol. 38(12), pages 2859-2868, February.
    12. Yang Wang & Zhangsheng Yu, 2022. "A kernel regression model for panel count data with nonparametric covariate functions," Biometrics, The International Biometric Society, vol. 78(2), pages 586-597, June.
    13. Xingwei Tong & Xin He & Liuquan Sun & Jianguo Sun, 2009. "Variable Selection for Panel Count Data via Non‐Concave Penalized Estimating Function," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 36(4), pages 620-635, December.
    14. Jianhong Wang & Xiaoyan Lin, 2020. "A Bayesian approach for semiparametric regression analysis of panel count data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(2), pages 402-420, April.
    15. Xingwei Tong, 2011. "Comments on: Nonparametric inference based on panel count data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 58-61, May.
    16. Hui Zhao & Yang Li & Jianguo Sun, 2013. "Semiparametric analysis of multivariate panel count data with dependent observation processes and a terminal event," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 25(2), pages 379-394, June.
    17. Zhao, Xingqiu & Tong, Xingwei, 2011. "Semiparametric regression analysis of panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 291-300, January.
    18. Zhao, Xingqiu & Tong, Xingwei & Sun, Jianguo, 2013. "Robust estimation for panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 33-40.
    19. C.-Y. Huang & J. Qin & M.-C. Wang, 2010. "Semiparametric Analysis for Recurrent Event Data with Time-Dependent Covariates and Informative Censoring," Biometrics, The International Biometric Society, vol. 66(1), pages 39-49, March.
    20. Zhang, Haixiang & Zhao, Hui & Sun, Jianguo & Wang, Dehui & Kim, KyungMann, 2013. "Regression analysis of multivariate panel count data with an informative observation process," Journal of Multivariate Analysis, Elsevier, vol. 119(C), pages 71-80.
    21. Yang Li & Xin He & Haiying Wang & Jianguo Sun, 2016. "Regression analysis of longitudinal data with correlated censoring and observation times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 22(3), pages 343-362, July.
    22. Jie Zhou & Haixiang Zhang & Liuquan Sun & Jianguo Sun, 2017. "Joint analysis of panel count data with an informative observation process and a dependent terminal event," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(4), pages 560-584, October.
    23. Gang Cheng & Ying Zhang & Liqiang Lu, 2011. "Efficient algorithms for computing the non and semi-parametric maximum likelihood estimates with panel count data," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 23(2), pages 567-579.

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