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A semiparametric regression cure model with current status data

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  • K. F. Lam
  • Hongqi Xue

Abstract

This paper considers the analysis of current status data with a cured proportion in the population using a mixture model that combines a logistic regression formulation for the probability of cure with a semiparametric regression model for the time to occurrence of the event. The semiparametric regression model belongs to the flexible class of partly linear models that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies were carried out to investigate the performance of the proposed method and the model is fitted to a dataset from a study of calcification of the hydrogel intraocular lenses, a complication of cataract treatment. Copyright 2005, Oxford University Press.

Suggested Citation

  • K. F. Lam & Hongqi Xue, 2005. "A semiparametric regression cure model with current status data," Biometrika, Biometrika Trust, vol. 92(3), pages 573-586, September.
    • Handle: RePEc:oup:biomet:v:92:y:2005:i:3:p:573-586
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    File URL: http://hdl.handle.net/10.1093/biomet/92.3.573
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    Citations

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    Cited by:

    1. Luis E. Nieto‐Barajas & Guosheng Yin, 2008. "Bayesian Semiparametric Cure Rate Model with an Unknown Threshold," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 35(3), pages 540-556, September.
    2. Leilei Zeng & Richard J. Cook & Theodore E. Warkentin, 2010. "Regression Analysis with a Misclassified Covariate from a Current Status Observation Scheme," Biometrics, The International Biometric Society, vol. 66(2), pages 415-425, June.
    3. Hu, Tao & Xiang, Liming, 2016. "Partially linear transformation cure models for interval-censored data," Computational Statistics & Data Analysis, Elsevier, vol. 93(C), pages 257-269.
    4. Yuan Wu & Christina D. Chambers & Ronghui Xu, 2019. "Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(3), pages 507-528, July.
    5. Li, Shuwei & Hu, Tao & Zhao, Xingqiu & Sun, Jianguo, 2019. "A class of semiparametric transformation cure models for interval-censored failure time data," Computational Statistics & Data Analysis, Elsevier, vol. 133(C), pages 153-165.
    6. Shu Jiang & Richard J. Cook, 2020. "A Mixture Model for Bivariate Interval-Censored Failure Times with Dependent Susceptibility," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(1), pages 37-62, April.
    7. Yeqian Liu & Tao Hu & Jianguo Sun, 2017. "Regression analysis of current status data in the presence of a cured subgroup and dependent censoring," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(4), pages 626-650, October.
    8. Hu, Tao & Xiang, Liming, 2013. "Efficient estimation for semiparametric cure models with interval-censored data," Journal of Multivariate Analysis, Elsevier, vol. 121(C), pages 139-151.
    9. Peijie Wang & Xingwei Tong & Jianguo Sun, 2018. "A semiparametric regression cure model for doubly censored data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(3), pages 492-508, July.
    10. Shuangge Ma, 2011. "Additive risk model for current status data with a cured subgroup," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 63(1), pages 117-134, February.
    11. Liu, Xiaoyu & Xiang, Liming, 2021. "Generalized accelerated hazards mixture cure models with interval-censored data," Computational Statistics & Data Analysis, Elsevier, vol. 161(C).
    12. Chun Yin Lee & Kin Yau Wong & K. F. Lam & Jinfeng Xu, 2022. "Analysis of clustered interval‐censored data using a class of semiparametric partly linear frailty transformation models," Biometrics, The International Biometric Society, vol. 78(1), pages 165-178, March.
    13. Guo-Liang Tian & Mingqiu Wang & Lixin Song, 2014. "Variable selection in the high-dimensional continuous generalized linear model with current status data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(3), pages 467-483, March.
    14. Vera G. Sibirtseva, 2014. "Computer-Based Processing Of Literary Works And Study Of Literature," HSE Working papers WP BRP 07/LNG/2014, National Research University Higher School of Economics.
    15. Shuying Wang & Chunjie Wang & Jianguo Sun, 2021. "An additive hazards cure model with informative interval censoring," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(2), pages 244-268, April.
    16. Guoqing Diao & Ao Yuan, 2019. "A class of semiparametric cure models with current status data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(1), pages 26-51, January.

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