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Doubly robust learning for estimating individualized treatment with censored data

Author

Listed:
  • Y. Q. Zhao
  • D. Zeng
  • E. B. Laber
  • R. Song
  • M. Yuan
  • M. R. Kosorok

Abstract

Individualized treatment rules recommend treatments based on individual patient characteristics in order to maximize clinical benefit. When the clinical outcome of interest is survival time, estimation is often complicated by censoring. We develop nonparametric methods for estimating an optimal individualized treatment rule in the presence of censored data. To adjust for censoring, we propose a doubly robust estimator which requires correct specification of either the censoring model or survival model, but not both; the method is shown to be Fisher consistent when either model is correct. Furthermore, we establish the convergence rate of the expected survival under the estimated optimal individualized treatment rule to the expected survival under the optimal individualized treatment rule. We illustrate the proposed methods using simulation study and data from a Phase III clinical trial on non-small cell lung cancer.

Suggested Citation

  • Y. Q. Zhao & D. Zeng & E. B. Laber & R. Song & M. Yuan & M. R. Kosorok, 2015. "Doubly robust learning for estimating individualized treatment with censored data," Biometrika, Biometrika Trust, vol. 102(1), pages 151-168.
    • Handle: RePEc:oup:biomet:v:102:y:2015:i:1:p:151-168.
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    File URL: http://hdl.handle.net/10.1093/biomet/asu050
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    Cited by:

    1. Q. Clairon & R. Henderson & N. J. Young & E. D. Wilson & C. J. Taylor, 2021. "Adaptive treatment and robust control," Biometrics, The International Biometric Society, vol. 77(1), pages 223-236, March.
    2. Jin Wang & Donglin Zeng & D. Y. Lin, 2022. "Semiparametric single-index models for optimal treatment regimens with censored outcomes," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(4), pages 744-763, October.
    3. Lingyun Lyu & Yu Cheng & Abdus S. Wahed, 2023. "Imputation‐based Q‐learning for optimizing dynamic treatment regimes with right‐censored survival outcome," Biometrics, The International Biometric Society, vol. 79(4), pages 3676-3689, December.
    4. He, Yizeng & Kim, Soyoung & Kim, Mi-Ok & Saber, Wael & Ahn, Kwang Woo, 2021. "Optimal treatment regimes for competing risk data using doubly robust outcome weighted learning with bi-level variable selection," Computational Statistics & Data Analysis, Elsevier, vol. 158(C).
    5. Ruohan Zhan & Zhimei Ren & Susan Athey & Zhengyuan Zhou, 2021. "Policy Learning with Adaptively Collected Data," Papers 2105.02344, arXiv.org, revised Nov 2022.
    6. Giorgos Bakoyannis, 2023. "Estimating optimal individualized treatment rules with multistate processes," Biometrics, The International Biometric Society, vol. 79(4), pages 2830-2842, December.
    7. Dana Johnson & Wenbin Lu & Marie Davidian, 2023. "A general framework for subgroup detection via one‐step value difference estimation," Biometrics, The International Biometric Society, vol. 79(3), pages 2116-2126, September.
    8. Yingchao Zhong & Chang Wang & Lu Wang, 2021. "Survival Augmented Patient Preference Incorporated Reinforcement Learning to Evaluate Tailoring Variables for Personalized Healthcare," Stats, MDPI, vol. 4(4), pages 1-17, September.
    9. Runchao Jiang & Wenbin Lu & Rui Song & Marie Davidian, 2017. "On estimation of optimal treatment regimes for maximizing t-year survival probability," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 79(4), pages 1165-1185, September.
    10. Emily L. Butler & Eric B. Laber & Sonia M. Davis & Michael R. Kosorok, 2018. "Incorporating Patient Preferences into Estimation of Optimal Individualized Treatment Rules," Biometrics, The International Biometric Society, vol. 74(1), pages 18-26, March.
    11. I Díaz & O Savenkov & K Ballman, 2018. "Targeted learning ensembles for optimal individualized treatment rules with time-to-event outcomes," Biometrika, Biometrika Trust, vol. 105(3), pages 723-738.
    12. Zhang, Haixiang & Huang, Jian & Sun, Liuquan, 2020. "A rank-based approach to estimating monotone individualized two treatment regimes," Computational Statistics & Data Analysis, Elsevier, vol. 151(C).
    13. Yunan Wu & Lan Wang, 2021. "Resampling‐based confidence intervals for model‐free robust inference on optimal treatment regimes," Biometrics, The International Biometric Society, vol. 77(2), pages 465-476, June.

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