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CD45-PET is a robust, non-invasive tool for imaging inflammation

Author

Listed:
  • Ali Salehi Farid

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jennifer E. Rowley

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Harris H. Allen

    (Dana-Farber Cancer Institute)

  • Isabella G. Kruger

    (Dana-Farber Cancer Institute)

  • Soheil Tavakolpour

    (Dana-Farber Cancer Institute)

  • Kyle Neeley

    (Dana-Farber Cancer Institute)

  • Min Cong

    (Dana-Farber Cancer Institute)

  • Haneyeh Shahbazian

    (Dana-Farber Cancer Institute)

  • Niki Dorafshani

    (Dana-Farber Cancer Institute)

  • Achraf Berrada

    (Dana-Farber Cancer Institute)

  • Alexander C. MacDonagh

    (Massachusetts General Hospital)

  • Robert F. Padera

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Pedro Brugarolas

    (Harvard Medical School
    Massachusetts General Hospital)

  • Alan B. Packard

    (Harvard Medical School
    Boston Children’s Hospital)

  • Matthew W. Rosenbaum

    (Harvard Medical School
    Harvard Medical School)

  • Sanjay Divakaran

    (Harvard Medical School
    Brigham and Women’s Hospital, Harvard Medical School
    Brigham and Women’s Hospital, Harvard Medical School)

  • Marcelo F. Carli

    (Harvard Medical School
    Brigham and Women’s Hospital, Harvard Medical School
    Brigham and Women’s Hospital, Harvard Medical School)

  • Mohammad Rashidian

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Parker Institute for Cancer Immunotherapy
    Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1–3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models. Notably, the intensity of the CD45-PET signal correlates robustly with the severity of disease in models of inflammatory lung and bowel diseases, outperforming 18F-fluorodeoxyglucose PET, the most widely used imaging modality for inflammation globally. Longitudinal CD45-PET imaging further enables precise monitoring of dynamic changes in tissue-specific inflammatory profiles. Finally, we developed a human CD45-PET probe for clinical translation that effectively detects human immune cells in a humanized mouse model. CD45-PET imaging holds substantial clinical promise, offering a tool for guiding diagnostic and therapeutic decisions for inflammatory diseases through a precise, whole-body assessment of the inflammation profiles of individual patients.

Suggested Citation

  • Ali Salehi Farid & Jennifer E. Rowley & Harris H. Allen & Isabella G. Kruger & Soheil Tavakolpour & Kyle Neeley & Min Cong & Haneyeh Shahbazian & Niki Dorafshani & Achraf Berrada & Alexander C. MacDon, 2025. "CD45-PET is a robust, non-invasive tool for imaging inflammation," Nature, Nature, vol. 639(8053), pages 214-224, March.
    • Handle: RePEc:nat:nature:v:639:y:2025:i:8053:d:10.1038_s41586-024-08441-6
    DOI: 10.1038/s41586-024-08441-6
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