IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v611y2022i7937d10.1038_s41586-022-05395-5.html
   My bibliography  Save this article

Non-redundant functions of group 2 innate lymphoid cells

Author

Listed:
  • Katja J. Jarick

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Patrycja M. Topczewska

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Manuel O. Jakob

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Hiroshi Yano

    (Weill Cornell Medicine
    Weill Cornell Medicine, Cornell University
    Weill Cornell Medicine, Cornell University)

  • Mohammad Arifuzzaman

    (Weill Cornell Medicine
    Weill Cornell Medicine, Cornell University
    Weill Cornell Medicine, Cornell University)

  • Xuemei Gao

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Sotiria Boulekou

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Vladislava Stokic-Trtica

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Pierre S. Leclère

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Alexandra Preußer

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Zoe A. Rompe

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Anton Stamm

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Amy M. Tsou

    (Weill Cornell Medicine
    Weill Cornell Medical College)

  • Coco Chu

    (Weill Cornell Medicine)

  • Frederik R. Heinrich

    (an Institute of the Leibniz Association)

  • Gabriela M. Guerra

    (an Institute of the Leibniz Association)

  • Pawel Durek

    (an Institute of the Leibniz Association)

  • Andranik Ivanov

    (Berlin Institute of Health at Charité–Universitätsmedizin Berlin)

  • Dieter Beule

    (Berlin Institute of Health at Charité–Universitätsmedizin Berlin)

  • Sofia Helfrich

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Claudia U. Duerr

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Anja A. Kühl

    (Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Christina Stehle

    (an Institute of the Leibniz Association
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Hindenburgdamm 30, 12203)

  • Chiara Romagnani

    (an Institute of the Leibniz Association
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Hindenburgdamm 30, 12203
    Leibniz–Science Campus Chronic Inflammation)

  • Mir-Farzin Mashreghi

    (an Institute of the Leibniz Association)

  • Andreas Diefenbach

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    an Institute of the Leibniz Association)

  • David Artis

    (Weill Cornell Medicine
    Weill Cornell Medicine, Cornell University
    Weill Cornell Medicine, Cornell University
    Cornell University)

  • Christoph S. N. Klose

    (Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

Abstract

Protective immunity relies on the interplay of innate and adaptive immune cells with complementary and redundant functions. Innate lymphoid cells (ILCs) have recently emerged as tissue-resident, innate mirror images of the T cell system, with which they share lineage-specifying transcription factors and effector machinery1. Located at barrier surfaces, ILCs are among the first responders against invading pathogens and thus could potentially determine the outcome of the immune response2. However, so far it has not been possible to dissect the unique contributions of ILCs to protective immunity owing to limitations in specific targeting of ILC subsets. Thus, all of the available data have been generated either in mice lacking the adaptive immune system or with tools that also affect other immune cell subsets. In addition, it has been proposed that ILCs might be dispensable for a proper immune response because other immune cells could compensate for their absence3–7. Here we report the generation of a mouse model based on the neuromedin U receptor 1 (Nmur1) promoter as a driver for simultaneous expression of Cre recombinase and green fluorescent protein, which enables gene targeting in group 2 ILCs (ILC2s) without affecting other innate and adaptive immune cells. Using Cre-mediated gene deletion of Id2 and Gata3 in Nmur1-expressing cells, we generated mice with a selective and specific deficiency in ILC2s. ILC2-deficient mice have decreased eosinophil counts at steady state and are unable to recruit eosinophils to the airways in models of allergic asthma. Further, ILC2-deficient mice do not mount an appropriate immune and epithelial type 2 response, resulting in a profound defect in worm expulsion and a non-protective type 3 immune response. In total, our data establish non-redundant functions for ILC2s in the presence of adaptive immune cells at steady state and during disease and argue for a multilayered organization of the immune system on the basis of a spatiotemporal division of labour.

Suggested Citation

  • Katja J. Jarick & Patrycja M. Topczewska & Manuel O. Jakob & Hiroshi Yano & Mohammad Arifuzzaman & Xuemei Gao & Sotiria Boulekou & Vladislava Stokic-Trtica & Pierre S. Leclère & Alexandra Preußer & Zo, 2022. "Non-redundant functions of group 2 innate lymphoid cells," Nature, Nature, vol. 611(7937), pages 794-800, November.
  • Handle: RePEc:nat:nature:v:611:y:2022:i:7937:d:10.1038_s41586-022-05395-5
    DOI: 10.1038/s41586-022-05395-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-022-05395-5
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-022-05395-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuande Wang & Yuhe Quan & Junming He & Shasha Chen & Zhongjun Dong, 2024. "SLAM-family receptors promote resolution of ILC2-mediated inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:611:y:2022:i:7937:d:10.1038_s41586-022-05395-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.