Author
Listed:
- Peter J. Halfmann
(University of Wisconsin-Madison)
- Shun Iida
(National Institute of Infectious Diseases)
- Kiyoko Iwatsuki-Horimoto
(Institute of Medical Science, University of Tokyo)
- Tadashi Maemura
(University of Wisconsin-Madison)
- Maki Kiso
(Institute of Medical Science, University of Tokyo)
- Suzanne M. Scheaffer
(Washington University School of Medicine)
- Tamarand L. Darling
(Washington University School of Medicine)
- Astha Joshi
(Washington University School of Medicine)
- Samantha Loeber
(University of Wisconsin–Madison)
- Gagandeep Singh
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Stephanie L. Foster
(Emory University School of Medicine)
- Baoling Ying
(Washington University School of Medicine)
- James Brett Case
(Washington University School of Medicine)
- Zhenlu Chong
(Washington University School of Medicine)
- Bradley Whitener
(Washington University School of Medicine)
- Juan Moliva
(National Institutes of Health)
- Katharine Floyd
(Emory University School of Medicine)
- Michiko Ujie
(Institute of Medical Science, University of Tokyo)
- Noriko Nakajima
(National Institute of Infectious Diseases)
- Mutsumi Ito
(Institute of Medical Science, University of Tokyo)
- Ryan Wright
(University of Wisconsin-Madison)
- Ryuta Uraki
(Institute of Medical Science, University of Tokyo
National Center for Global Health and Medicine Research Institute)
- Prajakta Warang
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Matthew Gagne
(National Institutes of Health)
- Rong Li
(Utah State University)
- Yuko Sakai-Tagawa
(Institute of Medical Science, University of Tokyo)
- Yanan Liu
(Utah State University)
- Deanna Larson
(Utah State University)
- Jorge E. Osorio
(University of Wisconsin
Universidad Nacional de Colombia)
- Juan P. Hernandez-Ortiz
(Universidad Nacional de Colombia)
- Amy R. Henry
(National Institutes of Health)
- Karl Ciuoderis
(Universidad Nacional de Colombia)
- Kelsey R. Florek
(Wisconsin State Laboratory of Hygiene)
- Mit Patel
(Emory University School of Medicine)
- Abby Odle
(University of Iowa)
- Lok-Yin Roy Wong
(University of Iowa)
- Allen C. Bateman
(Wisconsin State Laboratory of Hygiene)
- Zhongde Wang
(Utah State University)
- Venkata-Viswanadh Edara
(Emory University School of Medicine)
- Zhenlu Chong
(Washington University School of Medicine)
- John Franks
(St Jude Children’s Research Hospital)
- Trushar Jeevan
(St Jude Children’s Research Hospital)
- Thomas Fabrizio
(St Jude Children’s Research Hospital)
- Jennifer DeBeauchamp
(St Jude Children’s Research Hospital)
- Lisa Kercher
(St Jude Children’s Research Hospital)
- Patrick Seiler
(St Jude Children’s Research Hospital)
- Ana Silvia Gonzalez-Reiche
(Icahn School of Medicine at Mount Sinai)
- Emilia Mia Sordillo
(Icahn School of Medicine at Mount Sinai)
- Lauren A. Chang
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Harm Bakel
(Icahn School of Medicine at Mount Sinai)
- Viviana Simon
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Daniel C. Douek
(National Institutes of Health)
- Nancy J. Sullivan
(National Institutes of Health)
- Larissa B. Thackray
(Washington University School of Medicine)
- Hiroshi Ueki
(Institute of Medical Science, University of Tokyo
National Center for Global Health and Medicine Research Institute)
- Seiya Yamayoshi
(Institute of Medical Science, University of Tokyo
National Center for Global Health and Medicine Research Institute)
- Masaki Imai
(Institute of Medical Science, University of Tokyo
National Center for Global Health and Medicine Research Institute)
- Stanley Perlman
(University of Iowa)
- Richard J. Webby
(St Jude Children’s Research Hospital)
- Robert A. Seder
(National Institutes of Health)
- Mehul S. Suthar
(Emory University School of Medicine
Emory University)
- Adolfo García-Sastre
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Michael Schotsaert
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Tadaki Suzuki
(National Institute of Infectious Diseases)
- Adrianus C. M. Boon
(Washington University School of Medicine
Washington University School of Medicine
Washington University School of Medicine)
- Michael S. Diamond
(Washington University School of Medicine
Washington University School of Medicine
Washington University School of Medicine
Washington University School of Medicine)
- Yoshihiro Kawaoka
(University of Wisconsin-Madison
Institute of Medical Science, University of Tokyo
National Center for Global Health and Medicine Research Institute)
Abstract
The recent emergence of B.1.1.529, the Omicron variant1,2, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. 3,4), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.
Suggested Citation
Peter J. Halfmann & Shun Iida & Kiyoko Iwatsuki-Horimoto & Tadashi Maemura & Maki Kiso & Suzanne M. Scheaffer & Tamarand L. Darling & Astha Joshi & Samantha Loeber & Gagandeep Singh & Stephanie L. Fos, 2022.
"SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters,"
Nature, Nature, vol. 603(7902), pages 687-692, March.
Handle:
RePEc:nat:nature:v:603:y:2022:i:7902:d:10.1038_s41586-022-04441-6
DOI: 10.1038/s41586-022-04441-6
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