IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v603y2022i7902d10.1038_s41586-022-04441-6.html
   My bibliography  Save this article

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Author

Listed:
  • Peter J. Halfmann

    (University of Wisconsin-Madison)

  • Shun Iida

    (National Institute of Infectious Diseases)

  • Kiyoko Iwatsuki-Horimoto

    (Institute of Medical Science, University of Tokyo)

  • Tadashi Maemura

    (University of Wisconsin-Madison)

  • Maki Kiso

    (Institute of Medical Science, University of Tokyo)

  • Suzanne M. Scheaffer

    (Washington University School of Medicine)

  • Tamarand L. Darling

    (Washington University School of Medicine)

  • Astha Joshi

    (Washington University School of Medicine)

  • Samantha Loeber

    (University of Wisconsin–Madison)

  • Gagandeep Singh

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Stephanie L. Foster

    (Emory University School of Medicine)

  • Baoling Ying

    (Washington University School of Medicine)

  • James Brett Case

    (Washington University School of Medicine)

  • Zhenlu Chong

    (Washington University School of Medicine)

  • Bradley Whitener

    (Washington University School of Medicine)

  • Juan Moliva

    (National Institutes of Health)

  • Katharine Floyd

    (Emory University School of Medicine)

  • Michiko Ujie

    (Institute of Medical Science, University of Tokyo)

  • Noriko Nakajima

    (National Institute of Infectious Diseases)

  • Mutsumi Ito

    (Institute of Medical Science, University of Tokyo)

  • Ryan Wright

    (University of Wisconsin-Madison)

  • Ryuta Uraki

    (Institute of Medical Science, University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Prajakta Warang

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Matthew Gagne

    (National Institutes of Health)

  • Rong Li

    (Utah State University)

  • Yuko Sakai-Tagawa

    (Institute of Medical Science, University of Tokyo)

  • Yanan Liu

    (Utah State University)

  • Deanna Larson

    (Utah State University)

  • Jorge E. Osorio

    (University of Wisconsin
    Universidad Nacional de Colombia)

  • Juan P. Hernandez-Ortiz

    (Universidad Nacional de Colombia)

  • Amy R. Henry

    (National Institutes of Health)

  • Karl Ciuoderis

    (Universidad Nacional de Colombia)

  • Kelsey R. Florek

    (Wisconsin State Laboratory of Hygiene)

  • Mit Patel

    (Emory University School of Medicine)

  • Abby Odle

    (University of Iowa)

  • Lok-Yin Roy Wong

    (University of Iowa)

  • Allen C. Bateman

    (Wisconsin State Laboratory of Hygiene)

  • Zhongde Wang

    (Utah State University)

  • Venkata-Viswanadh Edara

    (Emory University School of Medicine)

  • Zhenlu Chong

    (Washington University School of Medicine)

  • John Franks

    (St Jude Children’s Research Hospital)

  • Trushar Jeevan

    (St Jude Children’s Research Hospital)

  • Thomas Fabrizio

    (St Jude Children’s Research Hospital)

  • Jennifer DeBeauchamp

    (St Jude Children’s Research Hospital)

  • Lisa Kercher

    (St Jude Children’s Research Hospital)

  • Patrick Seiler

    (St Jude Children’s Research Hospital)

  • Ana Silvia Gonzalez-Reiche

    (Icahn School of Medicine at Mount Sinai)

  • Emilia Mia Sordillo

    (Icahn School of Medicine at Mount Sinai)

  • Lauren A. Chang

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Harm Bakel

    (Icahn School of Medicine at Mount Sinai)

  • Viviana Simon

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Daniel C. Douek

    (National Institutes of Health)

  • Nancy J. Sullivan

    (National Institutes of Health)

  • Larissa B. Thackray

    (Washington University School of Medicine)

  • Hiroshi Ueki

    (Institute of Medical Science, University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Seiya Yamayoshi

    (Institute of Medical Science, University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Masaki Imai

    (Institute of Medical Science, University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Stanley Perlman

    (University of Iowa)

  • Richard J. Webby

    (St Jude Children’s Research Hospital)

  • Robert A. Seder

    (National Institutes of Health)

  • Mehul S. Suthar

    (Emory University School of Medicine
    Emory University)

  • Adolfo García-Sastre

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Michael Schotsaert

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Tadaki Suzuki

    (National Institute of Infectious Diseases)

  • Adrianus C. M. Boon

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Yoshihiro Kawaoka

    (University of Wisconsin-Madison
    Institute of Medical Science, University of Tokyo
    National Center for Global Health and Medicine Research Institute)

Abstract

The recent emergence of B.1.1.529, the Omicron variant1,2, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. 3,4), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.

Suggested Citation

  • Peter J. Halfmann & Shun Iida & Kiyoko Iwatsuki-Horimoto & Tadashi Maemura & Maki Kiso & Suzanne M. Scheaffer & Tamarand L. Darling & Astha Joshi & Samantha Loeber & Gagandeep Singh & Stephanie L. Fos, 2022. "SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters," Nature, Nature, vol. 603(7902), pages 687-692, March.
  • Handle: RePEc:nat:nature:v:603:y:2022:i:7902:d:10.1038_s41586-022-04441-6
    DOI: 10.1038/s41586-022-04441-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-022-04441-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-022-04441-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:603:y:2022:i:7902:d:10.1038_s41586-022-04441-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.