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Activation of TIR signalling boosts pattern-triggered immunity

Author

Listed:
  • Hainan Tian

    (University of British Columbia)

  • Zhongshou Wu

    (University of British Columbia
    University of British Columbia)

  • Siyu Chen

    (University of British Columbia
    Northeast Normal University
    Linyi University)

  • Kevin Ao

    (University of British Columbia
    University of British Columbia)

  • Weijie Huang

    (University of British Columbia)

  • Hoda Yaghmaiean

    (University of British Columbia)

  • Tongjun Sun

    (University of British Columbia)

  • Fang Xu

    (University of British Columbia
    University of British Columbia
    Shandong University)

  • Yanjun Zhang

    (University of British Columbia
    Zhejiang Normal University)

  • Shucai Wang

    (Linyi University)

  • Xin Li

    (University of British Columbia
    University of British Columbia)

  • Yuelin Zhang

    (University of British Columbia)

Abstract

Plant immune responses are mainly activated by two types of receptor. Pattern recognition receptors localized on the plasma membrane perceive extracellular microbial features, and nucleotide-binding leucine-rich repeat receptors (NLRs) recognize intracellular effector proteins from pathogens1. NLRs possessing amino-terminal Toll/interleukin-1 receptor (TIR) domains activate defence responses via the NADase activity of the TIR domain2,3. Here we report that activation of TIR signalling has a key role in pattern-triggered immunity (PTI) mediated by pattern recognition receptors. TIR signalling mutants exhibit attenuated PTI responses and decreased resistance against pathogens. Consistently, PTI is compromised in plants with reduced NLR levels. Treatment with the PTI elicitor flg22 or nlp20 rapidly induces many genes encoding TIR-domain-containing proteins, which is likely to be responsible for activating TIR signalling during PTI. Overall, our study reveals that activation of TIR signalling is an important mechanism for boosting plant defence during PTI.

Suggested Citation

  • Hainan Tian & Zhongshou Wu & Siyu Chen & Kevin Ao & Weijie Huang & Hoda Yaghmaiean & Tongjun Sun & Fang Xu & Yanjun Zhang & Shucai Wang & Xin Li & Yuelin Zhang, 2021. "Activation of TIR signalling boosts pattern-triggered immunity," Nature, Nature, vol. 598(7881), pages 500-503, October.
    • Handle: RePEc:nat:nature:v:598:y:2021:i:7881:d:10.1038_s41586-021-03987-1
    DOI: 10.1038/s41586-021-03987-1
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    Cited by:

    1. Shen Huang & Chunli Wang & Zixuan Ding & Yaqian Zhao & Jing Dai & Jia Li & Haining Huang & Tongkai Wang & Min Zhu & Mingfeng Feng & Yinghua Ji & Zhongkai Zhang & Xiaorong Tao, 2024. "A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jiahui Liu & Xiaoyun Wu & Yue Fang & Ye Liu & Esther Oreofe Bello & Yong Li & Ruyi Xiong & Yinzi Li & Zheng Qing Fu & Aiming Wang & Xiaofei Cheng, 2023. "A plant RNA virus inhibits NPR1 sumoylation and subverts NPR1-mediated plant immunity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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