IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v570y2019i7760d10.1038_s41586-019-1288-y.html
   My bibliography  Save this article

The digitization of organic synthesis

Author

Listed:
  • Ian W. Davies

    (Princeton University)

Abstract

Organic chemistry has largely been conducted in an ad hoc manner by academic laboratories that are funded by grants directed towards the investigation of specific goals or hypotheses. Although modern synthetic methods can provide access to molecules of considerable complexity, predicting the outcome of a single chemical reaction remains a major challenge. Improvements in the prediction of ‘above-the-arrow’ reaction conditions are needed to enable intelligent decision making to select an optimal synthetic sequence that is guided by metrics including efficiency, quality and yield. Methods for the communication and the sharing of data will need to evolve from traditional tools to machine-readable formats and open collaborative frameworks. This will accelerate innovation and require the creation of a chemistry commons with standardized data handling, curation and metrics.

Suggested Citation

  • Ian W. Davies, 2019. "The digitization of organic synthesis," Nature, Nature, vol. 570(7760), pages 175-181, June.
    • Handle: RePEc:nat:nature:v:570:y:2019:i:7760:d:10.1038_s41586-019-1288-y
    DOI: 10.1038/s41586-019-1288-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-019-1288-y
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-019-1288-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Artem I. Leonov & Alexander J. S. Hammer & Slawomir Lach & S. Hessam M. Mehr & Dario Caramelli & Davide Angelone & Aamir Khan & Steven O’Sullivan & Matthew Craven & Liam Wilbraham & Leroy Cronin, 2024. "An integrated self-optimizing programmable chemical synthesis and reaction engine," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:570:y:2019:i:7760:d:10.1038_s41586-019-1288-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.