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Optogenetic regulation of engineered cellular metabolism for microbial chemical production

Author

Listed:
  • Evan M. Zhao

    (Hoyt Laboratory, Princeton University)

  • Yanfei Zhang

    (Hoyt Laboratory, Princeton University)

  • Justin Mehl

    (Hoyt Laboratory, Princeton University)

  • Helen Park

    (Hoyt Laboratory, Princeton University)

  • Makoto A. Lalwani

    (Hoyt Laboratory, Princeton University)

  • Jared E. Toettcher

    (Department of Molecular Biology)

  • José L. Avalos

    (Hoyt Laboratory, Princeton University
    The Andlinger Center for Energy and the Environment, Princeton University)

Abstract

Finely tuned optogenetic control of engineered Saccharomyces cerevisiae enhances the biosynthesis of valuable products such as isobutanol in laboratory-scale fermenters.

Suggested Citation

  • Evan M. Zhao & Yanfei Zhang & Justin Mehl & Helen Park & Makoto A. Lalwani & Jared E. Toettcher & José L. Avalos, 2018. "Optogenetic regulation of engineered cellular metabolism for microbial chemical production," Nature, Nature, vol. 555(7698), pages 683-687, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7698:d:10.1038_nature26141
    DOI: 10.1038/nature26141
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    Citations

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    Cited by:

    1. Wenwen Diao & Liang Guo & Qiang Ding & Cong Gao & Guipeng Hu & Xiulai Chen & Yang Li & Linpei Zhang & Wei Chen & Jian Chen & Liming Liu, 2021. "Reprogramming microbial populations using a programmed lysis system to improve chemical production," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Vojislav Gligorovski & Ahmad Sadeghi & Sahand Jamal Rahi, 2023. "Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Sebastián Sosa-Carrillo & Henri Galez & Sara Napolitano & François Bertaux & Gregory Batt, 2023. "Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Michael B. Sheets & Nathan Tague & Mary J. Dunlop, 2023. "An optogenetic toolkit for light-inducible antibiotic resistance," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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