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Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

Author

Listed:
  • Isidoro Cobo

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO)

  • Paola Martinelli

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Medical University Vienna)

  • Marta Flández

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Spanish National Cardiovascular Research Centre-CNIC)

  • Latifa Bakiri

    (Genes, Development, and Disease Group, Spanish National Cancer Research Centre-CNIO)

  • Mingfeng Zhang

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Enrique Carrillo-de-Santa-Pau

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO)

  • Jinping Jia

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Víctor J. Sánchez-Arévalo Lobo

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Universidad Francisco de Vitoria)

  • Diego Megías

    (Confocal Microscopy Unit, Spanish National Cancer Research Centre-CNIO)

  • Irene Felipe

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO)

  • Natalia del Pozo

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, CIBERONC)

  • Irene Millán

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, CIBERONC)

  • Liv Thommesen

    (Norwegian University of Science and Technology (NTNU))

  • Torunn Bruland

    (Clinic of Medicine, St. Olav’s University Hospital
    Norwegian University of Science and Technology (NTNU))

  • Sara H. Olson

    (Memorial Sloan Kettering Cancer Center, New York)

  • Jill Smith

    (Georgetown University)

  • Kristina Schoonjans

    (Ecole Polytechnique Fédérale de Lausanne)

  • William R. Bamlet

    (Mayo Clinic)

  • Gloria M. Petersen

    (Mayo Clinic)

  • Núria Malats

    (Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre-CNIO
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre-CNIO, CIBERONC)

  • Laufey T. Amundadottir

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Erwin F. Wagner

    (Genes, Development, and Disease Group, Spanish National Cancer Research Centre-CNIO)

  • Francisco X. Real

    (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
    Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, CIBERONC
    Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra)

Abstract

In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state.

Suggested Citation

  • Isidoro Cobo & Paola Martinelli & Marta Flández & Latifa Bakiri & Mingfeng Zhang & Enrique Carrillo-de-Santa-Pau & Jinping Jia & Víctor J. Sánchez-Arévalo Lobo & Diego Megías & Irene Felipe & Natalia , 2018. "Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas," Nature, Nature, vol. 554(7693), pages 533-537, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25751
    DOI: 10.1038/nature25751
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    Citations

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    Cited by:

    1. Katelyn E. Connelly & Katherine Hullin & Ehssan Abdolalizadeh & Jun Zhong & Daina Eiser & Aidan O’Brien & Irene Collins & Sudipto Das & Gerard Duncan & Stephen J. Chanock & Rachael Z. Stolzenberg-Solo, 2025. "Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    2. Lukas Klein & Mengyu Tu & Niklas Krebs & Laura Urbach & Daniela Grimm & Muhammad Umair Latif & Frederike Penz & Anna Blandau & Xueyan Wu & Rebecca Diya Samuel & Stefan Küffer & Florian Wegwitz & Natha, 2025. "Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    3. Isidoro Cobo & Sumit Paliwal & Cristina Bodas & Irene Felipe & Júlia Melià-Alomà & Ariadna Torres & Jaime Martínez-Villarreal & Marina Malumbres & Fernando García & Irene Millán & Natalia Pozo & Joo-C, 2023. "NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Natasha Hui Jin Ng & Soumita Ghosh & Chek Mei Bok & Carmen Ching & Blaise Su Jun Low & Juin Ting Chen & Euodia Lim & María Clara Miserendino & Yaw Sing Tan & Shawn Hoon & Adrian Kee Keong Teo, 2024. "HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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