IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v554y2018i7692d10.1038_nature25486.html
   My bibliography  Save this article

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

Author

Listed:
  • Yvette C. Wong

    (Northwestern University Feinberg School of Medicine)

  • Daniel Ysselstein

    (Northwestern University Feinberg School of Medicine)

  • Dimitri Krainc

    (Northwestern University Feinberg School of Medicine)

Abstract

Formation of inter-organelle contacts between mitochondria and lysosomes, regulated by lysosomal RAB7 GTP hydrolysis, allows for bidirectional regulation of mitochondrial and lysosomal dynamics.

Suggested Citation

  • Yvette C. Wong & Daniel Ysselstein & Dimitri Krainc, 2018. "Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis," Nature, Nature, vol. 554(7692), pages 382-386, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25486
    DOI: 10.1038/nature25486
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25486
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25486?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kangqiang Qiu & Weiwei Zou & Hongbao Fang & Mingang Hao & Kritika Mehta & Zhiqi Tian & Jun-Lin Guan & Kai Zhang & Taosheng Huang & Jiajie Diao, 2022. "Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. George K. E. Umanah & Leire Abalde-Atristain & Mohammed Repon Khan & Jaba Mitra & Mohamad Aasif Dar & Melissa Chang & Kavya Tangella & Amy McNamara & Samuel Bennett & Rong Chen & Vasudha Aggarwal & Ma, 2022. "AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Gong-Her Wu & Charlene Smith-Geater & Jesús G. Galaz-Montoya & Yingli Gu & Sanket R. Gupte & Ranen Aviner & Patrick G. Mitchell & Joy Hsu & Ricardo Miramontes & Keona Q. Wang & Nicolette R. Geller & C, 2023. "CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Zoë P. Van Acker & Anika Perdok & Ruben Hellemans & Katherine North & Inge Vorsters & Cedric Cappel & Jonas Dehairs & Johannes V. Swinnen & Ragna Sannerud & Marine Bretou & Markus Damme & Wim Annaert, 2023. "Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Jasjot Singh & Hadeer Elhabashy & Pathma Muthukottiappan & Markus Stepath & Martin Eisenacher & Oliver Kohlbacher & Volkmar Gieselmann & Dominic Winter, 2022. "Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Ryouhei Tsutsumi & Beatrix Ueberheide & Feng-Xia Liang & Benjamin G. Neel & Ryuichi Sakai & Yoshiro Saito, 2024. "Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Claudio Bussi & Tiaan Heunis & Enrica Pellegrino & Elliott M. Bernard & Nourdine Bah & Mariana Silva Santos & Pierre Santucci & Beren Aylan & Angela Rodgers & Antony Fearns & Julia Mitschke & Christop, 2022. "Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25486. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.