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Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

Author

Listed:
  • Qicong Shen

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Qian Zhang

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
    Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Yang Shi

    (Institute of Immunology, Zhejiang University School of Medicine)

  • Qingzhu Shi

    (Institute of Immunology, Zhejiang University School of Medicine)

  • Yanyan Jiang

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Yan Gu

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Zhiqing Li

    (Institute of Immunology, Zhejiang University School of Medicine)

  • Xia Li

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Kai Zhao

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Chunmei Wang

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Nan Li

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Xuetao Cao

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
    Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

Abstract

A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

Suggested Citation

  • Qicong Shen & Qian Zhang & Yang Shi & Qingzhu Shi & Yanyan Jiang & Yan Gu & Zhiqing Li & Xia Li & Kai Zhao & Chunmei Wang & Nan Li & Xuetao Cao, 2018. "Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation," Nature, Nature, vol. 554(7690), pages 123-127, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25434
    DOI: 10.1038/nature25434
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    Cited by:

    1. Jianheng Liu & Tao Huang & Wanying Chen & Chenhui Ding & Tianxuan Zhao & Xueni Zhao & Bing Cai & Yusen Zhang & Song Li & Ling Zhang & Maoguang Xue & Xiuju He & Wanzhong Ge & Canquan Zhou & Yanwen Xu &, 2022. "Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. A. Emilia Arguello & Ang Li & Xuemeng Sun & Tanner W. Eggert & Elisabeth Mairhofer & Ralph E. Kleiner, 2022. "Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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