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Salt-responsive gut commensal modulates TH17 axis and disease

Author

Listed:
  • Nicola Wilck

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    DZHK (German Centre for Cardiovascular Research))

  • Mariana G. Matus

    (Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology
    Computational and Systems Biology Program, Massachusetts Institute of Technology)

  • Sean M. Kearney

    (Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology)

  • Scott W. Olesen

    (Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology)

  • Kristoffer Forslund

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Hendrik Bartolomaeus

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    DZHK (German Centre for Cardiovascular Research))

  • Stefanie Haase

    (Friedrich-Alexander-University Erlangen-Nuremberg)

  • Anja Mähler

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • András Balogh

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    DZHK (German Centre for Cardiovascular Research))

  • Lajos Markó

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    DZHK (German Centre for Cardiovascular Research))

  • Olga Vvedenskaya

    (Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    Integrative Proteomics and Metabolomics Platform, Berlin Institute for Medical Systems Biology BIMSB
    Berlin School of Integrative Oncology, Charité University Medicine Berlin)

  • Friedrich H. Kleiner

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin)

  • Dmitry Tsvetkov

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin)

  • Lars Klug

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • Paul I. Costea

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Shinichi Sunagawa

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit
    Institute of Microbiology, ETH Zurich)

  • Lisa Maier

    (European Molecular Biology Laboratory, Genome Biology Unit)

  • Natalia Rakova

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Friedrich-Alexander-University Erlangen-Nuremberg)

  • Valentin Schatz

    (Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg)

  • Patrick Neubert

    (Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg)

  • Christian Frätzer

    (Lipidomix GmbH)

  • Alexander Krannich

    (Berlin Institute of Health (BIH))

  • Maik Gollasch

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association)

  • Diana A. Grohme

    (Translational Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden)

  • Beatriz F. Côrte-Real

    (VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), Hasselt University, Campus Diepenbeek)

  • Roman G. Gerlach

    (Project Group 5, Robert Koch Institute)

  • Marijana Basic

    (Hannover Medical School, Institute for Laboratory Animal Science and Central Animal Facility)

  • Athanasios Typas

    (European Molecular Biology Laboratory, Genome Biology Unit)

  • Chuan Wu

    (Experimental Immunology Branch, National Cancer Institute, US National Institutes of Health)

  • Jens M. Titze

    (Vanderbilt University School of Medicine)

  • Jonathan Jantsch

    (Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg)

  • Michael Boschmann

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • Ralf Dechend

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • Markus Kleinewietfeld

    (Translational Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden
    VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), Hasselt University, Campus Diepenbeek
    Center for Regenerative Therapies Dresden (CRTD))

  • Stefan Kempa

    (Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    Berlin Institute of Health (BIH)
    Integrative Proteomics and Metabolomics Platform, Berlin Institute for Medical Systems Biology BIMSB)

  • Peer Bork

    (Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    European Molecular Biology Laboratory, Structural and Computational Biology Unit
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory
    Biocenter, University of Würzburg)

  • Ralf A. Linker

    (Friedrich-Alexander-University Erlangen-Nuremberg)

  • Eric J. Alm

    (Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology)

  • Dominik N. Müller

    (Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin
    Charité-Universitätsmedizin Berlin
    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    DZHK (German Centre for Cardiovascular Research))

Abstract

A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased TH17 cells and increased blood pressure. Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions.

Suggested Citation

  • Nicola Wilck & Mariana G. Matus & Sean M. Kearney & Scott W. Olesen & Kristoffer Forslund & Hendrik Bartolomaeus & Stefanie Haase & Anja Mähler & András Balogh & Lajos Markó & Olga Vvedenskaya & Fried, 2017. "Salt-responsive gut commensal modulates TH17 axis and disease," Nature, Nature, vol. 551(7682), pages 585-589, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7682:d:10.1038_nature24628
    DOI: 10.1038/nature24628
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    Cited by:

    1. Emanuele Rinninella & Marco Cintoni & Pauline Raoul & Antonio Gasbarrini & Maria Cristina Mele, 2020. "Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track," IJERPH, MDPI, vol. 17(23), pages 1-15, November.

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