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Association analysis identifies 65 new breast cancer risk loci

Author

Listed:
  • Kyriaki Michailidou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    The Cyprus Institute of Neurology and Genetics)

  • Sara Lindström

    (University of Washington School of Public Health
    Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health)

  • Joe Dennis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jonathan Beesley

    (QIMR Berghofer Medical Research Institute)

  • Shirley Hui

    (The Donnelly Centre, University of Toronto)

  • Siddhartha Kar

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Audrey Lemaçon

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Penny Soucy

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Dylan Glubb

    (QIMR Berghofer Medical Research Institute)

  • Asha Rostamianfar

    (The Donnelly Centre, University of Toronto)

  • Manjeet K. Bolla

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Qin Wang

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jonathan Tyrer

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Ed Dicks

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Andrew Lee

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Zhaoming Wang

    (St Jude Children’s Research Hospital
    Cancer Genomics Research Laboratory (CGR), National Cancer Institute)

  • Jamie Allen

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Renske Keeman

    (The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Ursula Eilber

    (German Cancer Research Center (DKFZ))

  • Juliet D. French

    (QIMR Berghofer Medical Research Institute)

  • Xiao Qing Chen

    (QIMR Berghofer Medical Research Institute)

  • Laura Fachal

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Karen McCue

    (QIMR Berghofer Medical Research Institute)

  • Amy E. McCart Reed

    (UQ Centre for Clinical Research, The University of Queensland)

  • Maya Ghoussaini

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jason S. Carroll

    (Cancer Research UK Cambridge Research Institute, University of Cambridge)

  • Xia Jiang

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health)

  • Hilary Finucane

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health
    Massachusetts Institute of Technology)

  • Marcia Adams

    (Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Muriel A. Adank

    (VU University Medical Center)

  • Habibul Ahsan

    (Center for Cancer Epidemiology and Prevention, The University of Chicago)

  • Kristiina Aittomäki

    (Helsinki University Hospital, University of Helsinki)

  • Hoda Anton-Culver

    (University of California Irvine)

  • Natalia N. Antonenkova

    (N. N. Alexandrov Research Institute of Oncology and Medical Radiology)

  • Volker Arndt

    (German Cancer Research Center (DKFZ))

  • Kristan J. Aronson

    (and Cancer Research Institute, Queen’s University)

  • Banu Arun

    (University of Texas MD Anderson Cancer Center)

  • Paul L. Auer

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center
    Zilber School of Public Health, University of Wisconsin-Milwaukee)

  • François Bacot

    (McGill University and Génome Québec Innovation Centre)

  • Myrto Barrdahl

    (German Cancer Research Center (DKFZ))

  • Caroline Baynes

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Matthias W. Beckmann

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Sabine Behrens

    (German Cancer Research Center (DKFZ))

  • Javier Benitez

    (Human Cancer Genetics Program, Spanish National Cancer Research Centre
    Centro de Investigación en Red de Enfermedades Raras (CIBERER))

  • Marina Bermisheva

    (Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences)

  • Leslie Bernstein

    (Beckman Research Institute of City of Hope)

  • Carl Blomqvist

    (Helsinki University Hospital, University of Helsinki)

  • Natalia V. Bogdanova

    (N. N. Alexandrov Research Institute of Oncology and Medical Radiology
    Hannover Medical School
    Gynaecology Research Unit, Hannover Medical School)

  • Stig E. Bojesen

    (Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital
    Herlev and Gentofte Hospital, Copenhagen University Hospital
    Faculty of Health and Medical Sciences, University of Copenhagen)

  • Bernardo Bonanni

    (Istituto Europeo di Oncologia)

  • Anne-Lise Børresen-Dale

    (Institute for Cancer Research, Oslo University Hospital Radiumhospitalet)

  • Judith S. Brand

    (Karolinska Institutet)

  • Hiltrud Brauch

    (Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

  • Paul Brennan

    (International Agency for Research on Cancer)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT))

  • Louise Brinton

    (National Cancer Institute, Rockville)

  • Per Broberg

    (Clinical Sciences, Lund University)

  • Ian W. Brock

    (Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield)

  • Annegien Broeks

    (The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Angela Brooks-Wilson

    (Genome Sciences Centre, BC Cancer Agency, Vancouver
    Simon Fraser University, Burnaby)

  • Sara Y. Brucker

    (University of Tübingen)

  • Thomas Brüning

    (Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum)

  • Barbara Burwinkel

    (University of Heidelberg
    Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ))

  • Katja Butterbach

    (German Cancer Research Center (DKFZ))

  • Qiuyin Cai

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Hui Cai

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Trinidad Caldés

    (Hospital Clínico San Carlos, IdISSC (Centro Investigacion Biomedica en Red), CIBERONC (Instituto de Investigación Sanitaria San Carlos))

  • Federico Canzian

    (Genomic Epidemiology Group, German Cancer Research Center (DKFZ))

  • Angel Carracedo

    (Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS
    Centro de Investigación en Red de Enfermedades Raras (CIBERER) y Centro Nacional de Genotipado (CEGEN-PRB2), Universidad de Santiago de Compostela)

  • Brian D. Carter

    (Epidemiology Research Program, American Cancer Society)

  • Jose E. Castelao

    (Oncology and Genetics Unit, Instituto de Investigacion Biomedica (IBI) Orense-Pontevedra-Vigo, Xerencia de Xestion Integrada de Vigo-SERGAS)

  • Tsun L. Chan

    (Hong Kong Hereditary Breast Cancer Family Registry
    Hong Kong Sanatorium and Hospital)

  • Ting-Yuan David Cheng

    (Roswell Park Cancer Institute)

  • Kee Seng Chia

    (Saw Swee Hock School of Public Health, National University of Singapore)

  • Ji-Yeob Choi

    (Seoul National University Graduate School
    Cancer Research Institute, Seoul National University)

  • Hans Christiansen

    (Hannover Medical School)

  • Christine L. Clarke

    (Westmead Institute for Medical Research, University of Sydney)

  • Margriet Collée

    (Erasmus University Medical Center)

  • Don M. Conroy

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Emilie Cordina-Duverger

    (Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay)

  • Sten Cornelissen

    (The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • David G. Cox

    (School of Public Health, Imperial College London
    INSERM U1052, Cancer Research Center of Lyon)

  • Angela Cox

    (Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield)

  • Simon S. Cross

    (Academic Unit of Pathology, University of Sheffield)

  • Julie M. Cunningham

    (Mayo Clinic)

  • Kamila Czene

    (Karolinska Institutet)

  • Mary B. Daly

    (Fox Chase Cancer Center)

  • Peter Devilee

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Kimberly F. Doheny

    (Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Thilo Dörk

    (Gynaecology Research Unit, Hannover Medical School)

  • Isabel dos-Santos-Silva

    (London School of Hygiene and Tropical Medicine)

  • Martine Dumont

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Lorraine Durcan

    (Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton
    Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton)

  • Miriam Dwek

    (Faculty of Science and Technology, University of Westminster)

  • Diana M. Eccles

    (Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton)

  • Arif B. Ekici

    (Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • A. Heather Eliassen

    (Brigham and Women’s Hospital, Harvard Medical School
    Harvard T. H. Chan School of Public Health)

  • Carolina Ellberg

    (Clinical Sciences, Lund University
    Oncology and Pathology, Lund University)

  • Mingajeva Elvira

    (Bashkir State University)

  • Christoph Engel

    (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
    LIFE—Leipzig Research Centre for Civilization Diseases, University of Leipzig)

  • Mikael Eriksson

    (Karolinska Institutet)

  • Peter A. Fasching

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
    David Geffen School of Medicine, University of California at Los Angeles)

  • Jonine Figueroa

    (National Cancer Institute, Rockville
    Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School)

  • Dieter Flesch-Janys

    (Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf
    Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf)

  • Olivia Fletcher

    (Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research)

  • Henrik Flyger

    (Herlev and Gentofte Hospital, Copenhagen University Hospital)

  • Lin Fritschi

    (School of Public Health, Curtin University)

  • Valerie Gaborieau

    (International Agency for Research on Cancer)

  • Marike Gabrielson

    (Karolinska Institutet)

  • Manuela Gago-Dominguez

    (Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS
    Moores Cancer Center, University of California San Diego)

  • Yu-Tang Gao

    (Shanghai Cancer Institute)

  • Susan M. Gapstur

    (Epidemiology Research Program, American Cancer Society)

  • José A. García-Sáenz

    (Hospital Clínico San Carlos, IdISSC (Centro Investigacion Biomedica en Red), CIBERONC (Instituto de Investigación Sanitaria San Carlos))

  • Mia M. Gaudet

    (Epidemiology Research Program, American Cancer Society)

  • Vassilios Georgoulias

    (University Hospital of Heraklion)

  • Graham G. Giles

    (Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Gord Glendon

    (Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)

  • Mark S. Goldberg

    (McGill University
    Royal Victoria Hospital, McGill University)

  • David E. Goldgar

    (Huntsman Cancer Institute, University of Utah School of Medicine)

  • Anna González-Neira

    (Human Cancer Genetics Program, Spanish National Cancer Research Centre)

  • Grethe I. Grenaker Alnæs

    (Institute for Cancer Research, Oslo University Hospital Radiumhospitalet)

  • Mervi Grip

    (Oulu University Hospital, University of Oulu)

  • Jacek Gronwald

    (Pomeranian Medical University)

  • Anne Grundy

    (Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Université de Montréal)

  • Pascal Guénel

    (Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay)

  • Lothar Haeberle

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Eric Hahnen

    (Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne
    Center for Integrated Oncology (CIO), University Hospital of Cologne
    Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Christopher A. Haiman

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Niclas Håkansson

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Ute Hamann

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ))

  • Nathalie Hamel

    (McGill University and Génome Québec Innovation Centre)

  • Susan Hankinson

    (University of Massachusetts, Amherst, Amherst)

  • Patricia Harrington

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Steven N. Hart

    (Mayo Clinic)

  • Jaana M. Hartikainen

    (Translational Cancer Research Area, University of Eastern Finland
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland
    Imaging Center, Kuopio University Hospital)

  • Mikael Hartman

    (Saw Swee Hock School of Public Health, National University of Singapore
    National University Health System)

  • Alexander Hein

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Jane Heyworth

    (School of Population Health, University of Western Australia)

  • Belynda Hicks

    (Cancer Genomics Research Laboratory (CGR), National Cancer Institute)

  • Peter Hillemanns

    (Gynaecology Research Unit, Hannover Medical School)

  • Dona N. Ho

    (Hong Kong Sanatorium and Hospital)

  • Antoinette Hollestelle

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • Maartje J. Hooning

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • Robert N. Hoover

    (National Cancer Institute, Rockville)

  • John L. Hopper

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Ming-Feng Hou

    (Kaohsiung Medical University)

  • Chia-Ni Hsiung

    (Institute of Biomedical Sciences, Academia Sinica)

  • Guanmengqian Huang

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ))

  • Keith Humphreys

    (Karolinska Institutet)

  • Junko Ishiguro

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

  • Hidemi Ito

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

  • Motoki Iwasaki

    (Center for Public Health Sciences, National Cancer Center)

  • Hiroji Iwata

    (Aichi Cancer Center Hospital)

  • Anna Jakubowska

    (Pomeranian Medical University)

  • Wolfgang Janni

    (University Hospital Ulm)

  • Esther M. John

    (Cancer Prevention Institute of California, Fremont
    Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine)

  • Nichola Johnson

    (Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research)

  • Kristine Jones

    (Cancer Genomics Research Laboratory (CGR), National Cancer Institute)

  • Michael Jones

    (The Institute of Cancer Research)

  • Arja Jukkola-Vuorinen

    (Oulu University Hospital, University of Oulu)

  • Rudolf Kaaks

    (German Cancer Research Center (DKFZ))

  • Maria Kabisch

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ))

  • Katarzyna Kaczmarek

    (Pomeranian Medical University)

  • Daehee Kang

    (Seoul National University Graduate School
    Cancer Research Institute, Seoul National University
    Seoul National University College of Medicine)

  • Yoshio Kasuga

    (Nagano Matsushiro General Hospital)

  • Michael J. Kerin

    (School of Medicine, National University of Ireland)

  • Sofia Khan

    (Helsinki University Hospital, University of Helsinki)

  • Elza Khusnutdinova

    (Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences
    Bashkir State University)

  • Johanna I. Kiiski

    (Helsinki University Hospital, University of Helsinki)

  • Sung-Won Kim

    (Daerim Saint Mary’s Hospital)

  • Julia A. Knight

    (Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    Dalla Lana School of Public Health, University of Toronto, Toronto)

  • Veli-Matti Kosma

    (Translational Cancer Research Area, University of Eastern Finland
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland
    Imaging Center, Kuopio University Hospital)

  • Vessela N. Kristensen

    (Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
    Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
    Oslo University Hospital, University of Oslo)

  • Ute Krüger

    (Clinical Sciences, Lund University)

  • Ava Kwong

    (Hong Kong Hereditary Breast Cancer Family Registry
    The University of Hong Kong
    Hong Kong Sanatorium and Hospital)

  • Diether Lambrechts

    (Vesalius Research Center, VIB
    Laboratory for Translational Genetics, University of Leuven)

  • Loic Le Marchand

    (University of Hawaii Cancer Center)

  • Eunjung Lee

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Min Hyuk Lee

    (Soonchunhyang University College of Medicine and Soonchunhyang University Hospital)

  • Jong Won Lee

    (University of Ulsan College of Medicine and Asan Medical Center)

  • Chuen Neng Lee

    (National University Health System
    Thoracic and Vascular Surgery, National University Health System)

  • Flavio Lejbkowicz

    (Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine)

  • Jingmei Li

    (Karolinska Institutet)

  • Jenna Lilyquist

    (Mayo Clinic)

  • Annika Lindblom

    (Karolinska Institutet)

  • Jolanta Lissowska

    (M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology)

  • Wing-Yee Lo

    (Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen)

  • Sibylle Loibl

    (German Breast Group GmbH)

  • Jirong Long

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Artitaya Lophatananon

    (Warwick Medical School, Warwick University
    Institute of Population Health, University of Manchester)

  • Jan Lubinski

    (Pomeranian Medical University)

  • Craig Luccarini

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Michael P. Lux

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Edmond S. K. Ma

    (Hong Kong Hereditary Breast Cancer Family Registry
    Hong Kong Sanatorium and Hospital)

  • Robert J. MacInnis

    (Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Tom Maishman

    (Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton
    Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton)

  • Enes Makalic

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Kathleen E. Malone

    (Epidemiology Program, Fred Hutchinson Cancer Research Center)

  • Ivana Maleva Kostovska

    (Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts)

  • Arto Mannermaa

    (Translational Cancer Research Area, University of Eastern Finland
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland
    Imaging Center, Kuopio University Hospital)

  • Siranoush Manoukian

    (Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT))

  • JoAnn E. Manson

    (Harvard T. H. Chan School of Public Health
    Brigham and Women’s Hospital, Harvard Medical School)

  • Sara Margolin

    (Karolinska Institutet)

  • Shivaani Mariapun

    (Cancer Research Malaysia, Subang Jaya)

  • Maria Elena Martinez

    (Moores Cancer Center, University of California San Diego
    University of California San Diego)

  • Keitaro Matsuo

    (Nagoya University Graduate School of Medicine
    Aichi Cancer Center Research Institute)

  • Dimitrios Mavroudis

    (University Hospital of Heraklion)

  • James McKay

    (International Agency for Research on Cancer)

  • Catriona McLean

    (Anatomical Pathology, The Alfred Hospital)

  • Hanne Meijers-Heijboer

    (VU University Medical Center)

  • Alfons Meindl

    (Technische Universität München)

  • Primitiva Menéndez

    (Servicio de Anatomía Patológica, Hospital Monte Naranco)

  • Usha Menon

    (Gynaecological Cancer Research Centre, Institute for Women’s Health, University College London)

  • Jeffery Meyer

    (Mayo Clinic)

  • Hui Miao

    (Saw Swee Hock School of Public Health, National University of Singapore)

  • Nicola Miller

    (School of Medicine, National University of Ireland)

  • Nur Aishah Mohd Taib

    (Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre)

  • Kenneth Muir

    (Warwick Medical School, Warwick University
    Institute of Population Health, University of Manchester)

  • Anna Marie Mulligan

    (University of Toronto
    Laboratory Medicine Program, University Health Network)

  • Claire Mulot

    (Université Paris Sorbonne Cité, INSERM UMR-S1147)

  • Susan L. Neuhausen

    (Beckman Research Institute of City of Hope)

  • Heli Nevanlinna

    (Helsinki University Hospital, University of Helsinki)

  • Patrick Neven

    (Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven)

  • Sune F. Nielsen

    (Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital
    Herlev and Gentofte Hospital, Copenhagen University Hospital)

  • Dong-Young Noh

    (Seoul National University College of Medicine)

  • Børge G. Nordestgaard

    (Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital
    Herlev and Gentofte Hospital, Copenhagen University Hospital
    Faculty of Health and Medical Sciences, University of Copenhagen)

  • Aaron Norman

    (Mayo Clinic)

  • Olufunmilayo I. Olopade

    (Center for Clinical Cancer Genetics and Global Health, The University of Chicago)

  • Janet E. Olson

    (Mayo Clinic)

  • Håkan Olsson

    (Clinical Sciences, Lund University)

  • Curtis Olswold

    (Mayo Clinic)

  • Nick Orr

    (Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research)

  • V. Shane Pankratz

    (University of New Mexico Health Sciences Center, University of New Mexico)

  • Sue K. Park

    (Seoul National University Graduate School
    Cancer Research Institute, Seoul National University
    Seoul National University College of Medicine)

  • Tjoung-Won Park-Simon

    (Gynaecology Research Unit, Hannover Medical School)

  • Rachel Lloyd

    (The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia)

  • Jose I. A. Perez

    (Servicio de Cirugía General y Especialidades, Hospital Monte Naranco)

  • Paolo Peterlongo

    (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology)

  • Julian Peto

    (London School of Hygiene and Tropical Medicine)

  • Kelly-Anne Phillips

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
    Peter MacCallum Cancer Center
    The University of Melbourne
    St Vincent’s Hospital, The University of Melbourne)

  • Mila Pinchev

    (Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine)

  • Dijana Plaseska-Karanfilska

    (Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts)

  • Ross Prentice

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Nadege Presneau

    (Faculty of Science and Technology, University of Westminster)

  • Darya Prokofyeva

    (Bashkir State University)

  • Elizabeth Pugh

    (Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Katri Pylkäs

    (Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu
    Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu)

  • Brigitte Rack

    (Ludwig-Maximilians University of Munich)

  • Paolo Radice

    (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT))

  • Nazneen Rahman

    (Section of Cancer Genetics, The Institute of Cancer Research)

  • Gadi Rennert

    (Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine)

  • Hedy S. Rennert

    (Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine)

  • Valerie Rhenius

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Atocha Romero

    (Hospital Clínico San Carlos, IdISSC (Centro Investigacion Biomedica en Red), CIBERONC (Instituto de Investigación Sanitaria San Carlos)
    Hospital Universitario Puerta de Hierro)

  • Jane Romm

    (Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Kathryn J. Ruddy

    (Mayo Clinic)

  • Thomas Rüdiger

    (Institute of Pathology, Staedtisches Klinikum Karlsruhe)

  • Anja Rudolph

    (German Cancer Research Center (DKFZ))

  • Matthias Ruebner

    (University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Emiel J. T. Rutgers

    (The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam)

  • Emmanouil Saloustros

    (Hereditary Cancer Clinic, University Hospital of Heraklion)

  • Dale P. Sandler

    (Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park)

  • Suleeporn Sangrajrang

    (National Cancer Institute)

  • Elinor J. Sawyer

    (Research Oncology, Guy’s Hospital, King’s College London)

  • Daniel F. Schmidt

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Rita K. Schmutzler

    (Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne
    Center for Integrated Oncology (CIO), University Hospital of Cologne
    Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Andreas Schneeweiss

    (University of Heidelberg
    National Center for Tumor Diseases, University of Heidelberg)

  • Minouk J. Schoemaker

    (The Institute of Cancer Research)

  • Fredrick Schumacher

    (Case Western Reserve University)

  • Peter Schürmann

    (Gynaecology Research Unit, Hannover Medical School)

  • Rodney J. Scott

    (Pathology North, John Hunter Hospital
    Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle)

  • Christopher Scott

    (Mayo Clinic)

  • Sheila Seal

    (Section of Cancer Genetics, The Institute of Cancer Research)

  • Caroline Seynaeve

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • Mitul Shah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Priyanka Sharma

    (University of Kansas Medical Center)

  • Chen-Yang Shen

    (School of Public Health, China Medical University
    Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica)

  • Grace Sheng

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Mark E. Sherman

    (National Cancer Institute)

  • Martha J. Shrubsole

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Xiao-Ou Shu

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Ann Smeets

    (Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven)

  • Christof Sohn

    (National Center for Tumor Diseases, University of Heidelberg)

  • Melissa C. Southey

    (Genetic Epidemiology Laboratory, The University of Melbourne)

  • John J. Spinelli

    (Cancer Control Research, BC Cancer Agency, Vancouver
    School of Population and Public Health, University of British Columbia, Vancouver)

  • Christa Stegmaier

    (Saarland Cancer Registry)

  • Sarah Stewart-Brown

    (Warwick Medical School, Warwick University)

  • Jennifer Stone

    (The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia
    University of Melbourne and the Royal Women’s Hospital)

  • Daniel O. Stram

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Harald Surowy

    (University of Heidelberg
    Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ))

  • Anthony Swerdlow

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Rulla Tamimi

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health
    Brigham and Women’s Hospital, Harvard Medical School
    Harvard T. H. Chan School of Public Health)

  • Jack A. Taylor

    (Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park
    Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park)

  • Maria Tengström

    (Translational Cancer Research Area, University of Eastern Finland
    Cancer Center, Kuopio University Hospital
    Institute of Clinical Medicine, Oncology, University of Eastern Finland)

  • Soo H. Teo

    (Cancer Research Malaysia, Subang Jaya
    Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre)

  • Mary Beth Terry

    (Mailman School of Public Health, Columbia University)

  • Daniel C. Tessier

    (McGill University and Génome Québec Innovation Centre)

  • Somchai Thanasitthichai

    (National Cancer Institute, Ministry of Public Health)

  • Kathrin Thöne

    (Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf)

  • Rob A. E. M. Tollenaar

    (Leiden University Medical Center)

  • Ian Tomlinson

    (Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford)

  • Ling Tong

    (Center for Cancer Epidemiology and Prevention, The University of Chicago)

  • Diana Torres

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
    Institute of Human Genetics, Pontificia Universidad Javeriana)

  • Thérèse Truong

    (Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay)

  • Chiu-Chen Tseng

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Shoichiro Tsugane

    (Center for Public Health Sciences, National Cancer Center)

  • Hans-Ulrich Ulmer

    (Frauenklinik der Stadtklinik Baden-Baden)

  • Giske Ursin

    (Cancer Registry of Norway
    Institute of Basic Medical Sciences, University of Oslo)

  • Michael Untch

    (Helios Clinics Berlin-Buch)

  • Celine Vachon

    (Mayo Clinic)

  • Christi J. van Asperen

    (Leiden University Medical Center)

  • David Van Den Berg

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Ans M. W. van den Ouweland

    (Erasmus University Medical Center)

  • Lizet van der Kolk

    (Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Rob B. van der Luijt

    (University Medical Center Utrecht)

  • Daniel Vincent

    (McGill University and Génome Québec Innovation Centre)

  • Jason Vollenweider

    (Mayo Clinic)

  • Quinten Waisfisz

    (VU University Medical Center)

  • Shan Wang-Gohrke

    (University of Ulm)

  • Clarice R. Weinberg

    (Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park)

  • Camilla Wendt

    (Karolinska Institutet)

  • Alice S. Whittemore

    (Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine)

  • Hans Wildiers

    (Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven)

  • Walter Willett

    (Harvard T. H. Chan School of Public Health
    Harvard T. H. Chan School of Public Health)

  • Robert Winqvist

    (Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu
    Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu)

  • Alicja Wolk

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Anna H. Wu

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Lucy Xia

    (Keck School of Medicine, University of Southern California, Los Angeles)

  • Taiki Yamaji

    (Center for Public Health Sciences, National Cancer Center)

  • Xiaohong R. Yang

    (National Cancer Institute, Rockville)

  • Cheng Har Yip

    (Subang Jaya Medical Centre, Subang Jaya)

  • Keun-Young Yoo

    (Seoul National University College of Medicine
    Armed Forces Capital Hospital)

  • Jyh-Cherng Yu

    (Tri-Service General Hospital, National Defense Medical Center)

  • Wei Zheng

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Ying Zheng

    (Shanghai Municipal Center for Disease Control and Prevention)

  • Bin Zhu

    (Cancer Genomics Research Laboratory (CGR), National Cancer Institute)

  • Argyrios Ziogas

    (University of California Irvine)

  • Elad Ziv

    (Institute for Human Genetics, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Sunil R. Lakhani

    (UQ Centre for Clinical Research, The University of Queensland
    Pathology Queensland, The Royal Brisbane and Women’s Hospital)

  • Antonis C. Antoniou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Arnaud Droit

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Irene L. Andrulis

    (Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    University of Toronto)

  • Christopher I. Amos

    (Center for Genomic Medicine, Geisel School of Medicine, Dartmouth College)

  • Fergus J. Couch

    (Mayo Clinic)

  • Paul D. P. Pharoah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ)
    University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf)

  • Per Hall

    (Karolinska Institutet
    Södersjukhuset)

  • David J. Hunter

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health
    Harvard T. H. Chan School of Public Health)

  • Roger L. Milne

    (Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Montserrat García-Closas

    (National Cancer Institute, Rockville)

  • Marjanka K. Schmidt

    (The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Stephen J. Chanock

    (National Cancer Institute, Rockville)

  • Alison M. Dunning

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Stacey L. Edwards

    (QIMR Berghofer Medical Research Institute)

  • Gary D. Bader

    (The Donnelly Centre, University of Toronto)

  • Georgia Chenevix-Trench

    (QIMR Berghofer Medical Research Institute)

  • Jacques Simard

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Peter Kraft

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health
    Harvard T. H. Chan School of Public Health)

  • Douglas F. Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    Centre for Cancer Genetic Epidemiology, University of Cambridge)

Abstract

Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

Suggested Citation

  • Kyriaki Michailidou & Sara Lindström & Joe Dennis & Jonathan Beesley & Shirley Hui & Siddhartha Kar & Audrey Lemaçon & Penny Soucy & Dylan Glubb & Asha Rostamianfar & Manjeet K. Bolla & Qin Wang & Jon, 2017. "Association analysis identifies 65 new breast cancer risk loci," Nature, Nature, vol. 551(7678), pages 92-94, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24284
    DOI: 10.1038/nature24284
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    1. Meghana Pagadala & Timothy J. Sears & Victoria H. Wu & Eva Pérez-Guijarro & Hyo Kim & Andrea Castro & James V. Talwar & Cristian Gonzalez-Colin & Steven Cao & Benjamin J. Schmiedel & Shervin Goudarzi , 2023. "Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Hui Chen & Zeyang Wang & Lihai Gong & Qixuan Wang & Wenyan Chen & Jia Wang & Xuelian Ma & Ruofan Ding & Xing Li & Xudong Zou & Mireya Plass & Cheng Lian & Ting Ni & Gong-Hong Wei & Wei Li & Lin Deng &, 2024. "A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
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    5. Go Sato & Yuya Shirai & Shinichi Namba & Ryuya Edahiro & Kyuto Sonehara & Tsuyoshi Hata & Mamoru Uemura & Koichi Matsuda & Yuichiro Doki & Hidetoshi Eguchi & Yukinori Okada, 2023. "Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    6. Wenhan Chen & Yang Wu & Zhili Zheng & Ting Qi & Peter M. Visscher & Zhihong Zhu & Jian Yang, 2021. "Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    7. Junhao Wen & Bingxin Zhao & Zhijian Yang & Guray Erus & Ioanna Skampardoni & Elizabeth Mamourian & Yuhan Cui & Gyujoon Hwang & Jingxuan Bao & Aleix Boquet-Pujadas & Zhen Zhou & Yogasudha Veturi & Mary, 2024. "The genetic architecture of multimodal human brain age," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Wei Jiang & Ling Chen & Matthew J. Girgenti & Hongyu Zhao, 2024. "Tuning parameters for polygenic risk score methods using GWAS summary statistics from training data," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Xiaoyu Song & Jiayi Ji & Joseph H. Rothstein & Stacey E. Alexeeff & Lori C. Sakoda & Adriana Sistig & Ninah Achacoso & Eric Jorgenson & Alice S. Whittemore & Robert J. Klein & Laurel A. Habel & Pei Wa, 2023. "MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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