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Hippo pathway deficiency reverses systolic heart failure after infarction

Author

Listed:
  • John P. Leach

    (Baylor College of Medicine, One Baylor Plaza)

  • Todd Heallen

    (The Texas Heart Institute)

  • Min Zhang

    (Baylor College of Medicine, One Baylor Plaza
    Shanghai Children’s Medical Center)

  • Mahdis Rahmani

    (The Texas Heart Institute)

  • Yuka Morikawa

    (The Texas Heart Institute)

  • Matthew C. Hill

    (Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza)

  • Ana Segura

    (The Texas Heart Institute)

  • James T. Willerson

    (The Texas Heart Institute)

  • James F. Martin

    (Baylor College of Medicine, One Baylor Plaza
    The Texas Heart Institute
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza
    Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza)

Abstract

Deletion of the Hippo pathway component Salvador in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumping function.

Suggested Citation

  • John P. Leach & Todd Heallen & Min Zhang & Mahdis Rahmani & Yuka Morikawa & Matthew C. Hill & Ana Segura & James T. Willerson & James F. Martin, 2017. "Hippo pathway deficiency reverses systolic heart failure after infarction," Nature, Nature, vol. 550(7675), pages 260-264, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24045
    DOI: 10.1038/nature24045
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