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Orthotopic patient-derived xenografts of paediatric solid tumours

Author

Listed:
  • Elizabeth Stewart

    (St. Jude Children’s Research Hospital, Memphis
    St. Jude Children’s Research Hospital)

  • Sara M. Federico

    (St. Jude Children’s Research Hospital, Memphis)

  • Xiang Chen

    (St. Jude Children’s Research Hospital)

  • Anang A. Shelat

    (St. Jude Children’s Research Hospital)

  • Cori Bradley

    (St. Jude Children’s Research Hospital)

  • Brittney Gordon

    (St. Jude Children’s Research Hospital
    St. Jude Children’s Research Hospital)

  • Asa Karlstrom

    (St. Jude Children’s Research Hospital)

  • Nathaniel R. Twarog

    (St. Jude Children’s Research Hospital)

  • Michael R. Clay

    (St. Jude Children’s Research Hospital)

  • Armita Bahrami

    (St. Jude Children’s Research Hospital)

  • Burgess B. Freeman

    (St. Jude Children’s Research Hospital)

  • Beisi Xu

    (St. Jude Children’s Research Hospital)

  • Xin Zhou

    (St. Jude Children’s Research Hospital)

  • Jianrong Wu

    (St. Jude Children’s Research Hospital)

  • Victoria Honnell

    (St. Jude Children’s Research Hospital)

  • Monica Ocarz

    (St. Jude Children’s Research Hospital, Memphis)

  • Kaley Blankenship

    (St. Jude Children’s Research Hospital, Memphis)

  • Jason Dapper

    (St. Jude Children’s Research Hospital)

  • Elaine R. Mardis

    (The Genome Institute, Washington University School of Medicine in St. Louis
    Washington University School of Medicine in St. Louis
    Siteman Cancer Center, Washington University School of Medicine in St. Louis)

  • Richard K. Wilson

    (The Genome Institute, Washington University School of Medicine in St. Louis
    Washington University School of Medicine in St. Louis
    Washington University School of Medicine in St. Louis)

  • James Downing

    (St. Jude Children’s Research Hospital)

  • Jinghui Zhang

    (St. Jude Children’s Research Hospital)

  • John Easton

    (St. Jude Children’s Research Hospital)

  • Alberto Pappo

    (St. Jude Children’s Research Hospital, Memphis)

  • Michael A. Dyer

    (St. Jude Children’s Research Hospital
    Howard Hughes Medical Institute
    University of Tennessee Health Science Center)

Abstract

A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.

Suggested Citation

  • Elizabeth Stewart & Sara M. Federico & Xiang Chen & Anang A. Shelat & Cori Bradley & Brittney Gordon & Asa Karlstrom & Nathaniel R. Twarog & Michael R. Clay & Armita Bahrami & Burgess B. Freeman & Bei, 2017. "Orthotopic patient-derived xenografts of paediatric solid tumours," Nature, Nature, vol. 549(7670), pages 96-100, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7670:d:10.1038_nature23647
    DOI: 10.1038/nature23647
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    Citations

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    Cited by:

    1. Humberto Contreras-Trujillo & Jiya Eerdeng & Samir Akre & Du Jiang & Jorge Contreras & Basia Gala & Mary C. Vergel-Rodriguez & Yeachan Lee & Aparna Jorapur & Areen Andreasian & Lisa Harton & Charles S, 2021. "Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. W. Dean Pontius & Ellen S. Hong & Zachary J. Faber & Jeremy Gray & Craig D. Peacock & Ian Bayles & Katreya Lovrenert & Diana H. Chin & Berkley E. Gryder & Cynthia F. Bartels & Peter C. Scacheri, 2023. "Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Flavia A. Graca & Mamta Rai & Liam C. Hunt & Anna Stephan & Yong-Dong Wang & Brittney Gordon & Ruishan Wang & Giovanni Quarato & Beisi Xu & Yiping Fan & Myriam Labelle & Fabio Demontis, 2022. "The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Funan He & Abhik M. Bandyopadhyay & Laura J. Klesse & Anna Rogojina & Sang H. Chun & Erin Butler & Taylor Hartshorne & Trevor Holland & Dawn Garcia & Korri Weldon & Luz-Nereida Perez Prado & Anne-Mari, 2023. "Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Silvia Pomella & Matteo Cassandri & Lucrezia D’Archivio & Antonella Porrazzo & Cristina Cossetti & Doris Phelps & Clara Perrone & Michele Pezzella & Antonella Cardinale & Marco Wachtel & Sara Aloisi &, 2023. "MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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