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Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Author

Listed:
  • Markus Brockmann

    (Netherlands Cancer Institute)

  • Vincent A. Blomen

    (Netherlands Cancer Institute)

  • Joppe Nieuwenhuis

    (Netherlands Cancer Institute)

  • Elmer Stickel

    (Netherlands Cancer Institute)

  • Matthijs Raaben

    (Netherlands Cancer Institute)

  • Onno B. Bleijerveld

    (Netherlands Cancer Institute)

  • A. F. Maarten Altelaar

    (Netherlands Cancer Institute
    Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht)

  • Lucas T. Jae

    (Netherlands Cancer Institute
    Ludwig-Maximilians-Universität München)

  • Thijn R. Brummelkamp

    (Netherlands Cancer Institute
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    Cancergenomics.nl)

Abstract

Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.

Suggested Citation

  • Markus Brockmann & Vincent A. Blomen & Joppe Nieuwenhuis & Elmer Stickel & Matthijs Raaben & Onno B. Bleijerveld & A. F. Maarten Altelaar & Lucas T. Jae & Thijn R. Brummelkamp, 2017. "Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling," Nature, Nature, vol. 546(7657), pages 307-311, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7657:d:10.1038_nature22376
    DOI: 10.1038/nature22376
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    Cited by:

    1. Anna Gogleva & Dimitris Polychronopoulos & Matthias Pfeifer & Vladimir Poroshin & Michaël Ughetto & Matthew J. Martin & Hannah Thorpe & Aurelie Bornot & Paul D. Smith & Ben Sidders & Jonathan R. Dry &, 2022. "Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Evelyn Fessler & Luisa Krumwiede & Lucas T. Jae, 2022. "DELE1 tracks perturbed protein import and processing in human mitochondria," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Georgi Apriamashvili & David W. Vredevoogd & Oscar Krijgsman & Onno B. Bleijerveld & Maarten A. Ligtenberg & Beaunelle Bruijn & Julia Boshuizen & Joleen J. H. Traets & Daniela D’Empaire Altimari & Ale, 2022. "Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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