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The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

Author

Listed:
  • Gabriele Varano

    (IFOM, the FIRC Institute of Molecular Oncology)

  • Simon Raffel

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine)

  • Martina Sormani

    (IFOM, the FIRC Institute of Molecular Oncology)

  • Federica Zanardi

    (IFOM, the FIRC Institute of Molecular Oncology)

  • Silvia Lonardi

    (Section of Pathology, University of Brescia)

  • Christin Zasada

    (Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association)

  • Laura Perucho

    (IFOM, the FIRC Institute of Molecular Oncology)

  • Valentina Petrocelli

    (IFOM, the FIRC Institute of Molecular Oncology)

  • Andrea Haake

    (Institute of Human Genetics, Christian-Albrechts-University Kiel)

  • Albert K. Lee

    (Columbia University)

  • Mattia Bugatti

    (Section of Pathology, University of Brescia)

  • Ulrike Paul

    (Institute of Human Genetics, Christian-Albrechts-University Kiel)

  • Eelco Van Anken

    (San Raffaele Scientific Institute)

  • Laura Pasqualucci

    (Herbert Irving Comprehensive Cancer Center, Columbia University)

  • Raul Rabadan

    (Columbia University)

  • Reiner Siebert

    (Institute of Human Genetics, Christian-Albrechts-University Kiel
    Institute of Human Genetics, University Hospital of Ulm)

  • Stefan Kempa

    (Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association)

  • Maurilio Ponzoni

    (Ateneo Vita Salute and San Raffaele Scientific Institute, Pathology and Lymphoid Malignancies Units)

  • Fabio Facchetti

    (Section of Pathology, University of Brescia)

  • Klaus Rajewsky

    (Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association)

  • Stefano Casola

    (IFOM, the FIRC Institute of Molecular Oncology)

Abstract

Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.

Suggested Citation

  • Gabriele Varano & Simon Raffel & Martina Sormani & Federica Zanardi & Silvia Lonardi & Christin Zasada & Laura Perucho & Valentina Petrocelli & Andrea Haake & Albert K. Lee & Mattia Bugatti & Ulrike P, 2017. "The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition," Nature, Nature, vol. 546(7657), pages 302-306, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7657:d:10.1038_nature22353
    DOI: 10.1038/nature22353
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