IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v545y2017i7655d10.1038_nature22396.html
   My bibliography  Save this article

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Author

Listed:
  • Sydney R. Gordon

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine)

  • Roy L. Maute

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Ben W. Dulken

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford Medical Scientist Training Program, Stanford University)

  • Gregor Hutter

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford University School of Medicine
    University Hospital Basel)

  • Benson M. George

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Melissa N. McCracken

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Rohit Gupta

    (Human Immune Monitoring Center Biobank, Stanford University School of Medicine)

  • Jonathan M. Tsai

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Rahul Sinha

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Daniel Corey

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Aaron M. Ring

    (Yale University School of Medicine)

  • Andrew J. Connolly

    (Stanford University Medical Center)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

Abstract

Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

Suggested Citation

  • Sydney R. Gordon & Roy L. Maute & Ben W. Dulken & Gregor Hutter & Benson M. George & Melissa N. McCracken & Rohit Gupta & Jonathan M. Tsai & Rahul Sinha & Daniel Corey & Aaron M. Ring & Andrew J. Conn, 2017. "PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity," Nature, Nature, vol. 545(7655), pages 495-499, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22396
    DOI: 10.1038/nature22396
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22396
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature22396?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chih-Wei Chou & Chia-Nung Hung & Cheryl Hsiang-Ling Chiu & Xi Tan & Meizhen Chen & Chien-Chin Chen & Moawiz Saeed & Che-Wei Hsu & Michael A. Liss & Chiou-Miin Wang & Zhao Lai & Nathaniel Alvarez & Paw, 2023. "Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Yonghyun Lee & Jongyoon Shinn & Cheng Xu & Hannah E. Dobson & Nouri Neamati & James J. Moon, 2023. "Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Xudong Wang & Siyu Su & Yuqing Zhu & Xiaolong Cheng & Chen Cheng & Leilei Chen & Anhua Lei & Li Zhang & Yuyan Xu & Dan Ye & Yi Zhang & Wei Li & Jin Zhang, 2023. "Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Mokarram Hossain & Raymond Shim & Woo-Yong Lee & Arlene H. Sharpe & Paul Kubes, 2022. "Gata6+ resident peritoneal macrophages promote the growth of liver metastasis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Shiqun Wang & Wei Yan & Lingkai Kong & Shuguang Zuo & Jingyi Wu & Chunxiao Zhu & Huaping Huang & Bohao He & Jie Dong & Jiwu Wei, 2023. "Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22396. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.