IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v544y2017i7650d10.1038_nature22044.html
   My bibliography  Save this article

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

Author

Listed:
  • Daniel R. Scoles

    (University of Utah)

  • Pratap Meera

    (University of California Los Angeles)

  • Matthew D. Schneider

    (University of Utah)

  • Sharan Paul

    (University of Utah)

  • Warunee Dansithong

    (University of Utah)

  • Karla P. Figueroa

    (University of Utah)

  • Gene Hung

    (Ionis Pharmaceuticals)

  • Frank Rigo

    (Ionis Pharmaceuticals)

  • C. Frank Bennett

    (Ionis Pharmaceuticals)

  • Thomas S. Otis

    (University of California Los Angeles
    †Present address: Roche Pharma Research and Early Development, Neuroscience, Ophthalmology & Rare Diseases, Roche Innovation Center Basel, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.)

  • Stefan M. Pulst

    (University of Utah)

Abstract

Antisense oligonucleotides against ATXN2 improved motor neuron function and restored firing frequency in cerebellar Purkinje cells in mouse models of spinocerebellar ataxia type 2.

Suggested Citation

  • Daniel R. Scoles & Pratap Meera & Matthew D. Schneider & Sharan Paul & Warunee Dansithong & Karla P. Figueroa & Gene Hung & Frank Rigo & C. Frank Bennett & Thomas S. Otis & Stefan M. Pulst, 2017. "Antisense oligonucleotide therapy for spinocerebellar ataxia type 2," Nature, Nature, vol. 544(7650), pages 362-366, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7650:d:10.1038_nature22044
    DOI: 10.1038/nature22044
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22044
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature22044?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. M. Alejandra Zeballos C. & Hayden J. Moore & Tyler J. Smith & Jackson E. Powell & Najah S. Ahsan & Sijia Zhang & Thomas Gaj, 2023. "Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Suijuan Zhong & Mengdi Wang & Luwei Huang & Youqiao Chen & Yuxin Ge & Jiyao Zhang & Yingchao Shi & Hao Dong & Xin Zhou & Bosong Wang & Tian Lu & Xiaoxi Jing & Yufeng Lu & Junjing Zhang & Xiaoqun Wang , 2023. "Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:544:y:2017:i:7650:d:10.1038_nature22044. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.