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Structural insights into adiponectin receptors suggest ceramidase activity

Author

Listed:
  • Ieva Vasiliauskaité-Brooks

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Remy Sounier

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Pascal Rochaix

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Gaëtan Bellot

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Mathieu Fortier

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • François Hoh

    (Centre de Biochimie Structurale, CNRS UMR 5048-INSERM 1054 University of Montpellier)

  • Luigi De Colibus

    (University of Oxford)

  • Chérine Bechara

    (Dynamique des Interactions Membranaires Normales et Pathologiques, CNRS UMR5235, University of Montpellier)

  • Essa M. Saied

    (Institute for chemistry, Humboldt-Universität zu Berlin
    Faculty of Science, Suez Canal University)

  • Christoph Arenz

    (Institute for chemistry, Humboldt-Universität zu Berlin)

  • Cédric Leyrat

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Sébastien Granier

    (Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

Abstract

Structures of the adiponectin receptors ADIPOR1 and ADIPOR2 combined with molecular dynamics simulations and enzymatic assays suggest that both receptors have intrinsic ceramidase activity.

Suggested Citation

  • Ieva Vasiliauskaité-Brooks & Remy Sounier & Pascal Rochaix & Gaëtan Bellot & Mathieu Fortier & François Hoh & Luigi De Colibus & Chérine Bechara & Essa M. Saied & Christoph Arenz & Cédric Leyrat & Séb, 2017. "Structural insights into adiponectin receptors suggest ceramidase activity," Nature, Nature, vol. 544(7648), pages 120-123, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7648:d:10.1038_nature21714
    DOI: 10.1038/nature21714
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    Citations

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    Cited by:

    1. Mario Ruiz & Ranjan Devkota & Dimitra Panagaki & Per-Olof Bergh & Delaney Kaper & Marcus Henricsson & Ali Nik & Kasparas Petkevicius & Johanna L. Höög & Mohammad Bohlooly-Y & Peter Carlsson & Jan Boré, 2022. "Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Dandan Qian & Ye Cong & Runhao Wang & Quan Chen & Chuangye Yan & Deshun Gong, 2023. "Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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