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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Author

Listed:
  • Justin Eyquem

    (Center for Cell Engineering and Immunology Program)

  • Jorge Mansilla-Soto

    (Center for Cell Engineering and Immunology Program)

  • Theodoros Giavridis

    (Center for Cell Engineering and Immunology Program)

  • Sjoukje J. C. van der Stegen

    (Center for Cell Engineering and Immunology Program)

  • Mohamad Hamieh

    (Center for Cell Engineering and Immunology Program)

  • Kristen M. Cunanan

    (Memorial Sloan Kettering Cancer Center)

  • Ashlesha Odak

    (Center for Cell Engineering and Immunology Program)

  • Mithat Gönen

    (Memorial Sloan Kettering Cancer Center)

  • Michel Sadelain

    (Center for Cell Engineering and Immunology Program)

Abstract

Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations.

Suggested Citation

  • Justin Eyquem & Jorge Mansilla-Soto & Theodoros Giavridis & Sjoukje J. C. van der Stegen & Mohamad Hamieh & Kristen M. Cunanan & Ashlesha Odak & Mithat Gönen & Michel Sadelain, 2017. "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection," Nature, Nature, vol. 543(7643), pages 113-117, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7643:d:10.1038_nature21405
    DOI: 10.1038/nature21405
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