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Genetic variants regulating expression levels and isoform diversity during embryogenesis

Author

Listed:
  • Enrico Cannavò

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Nils Koelling

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI))

  • Dermot Harnett

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • David Garfield

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Francesco P. Casale

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI))

  • Lucia Ciglar

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Hilary E. Gustafson

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Rebecca R. Viales

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Raquel Marco-Ferreres

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Jacob F. Degner

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Bingqing Zhao

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Oliver Stegle

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI))

  • Ewan Birney

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI))

  • Eileen E. M. Furlong

    (European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

Abstract

The effects of genetic variation on transcriptional and post-transcriptional regulation are systematically mapped across multiple stages of embryogenesis in eighty inbred Drosophila lines, identifying thousands of quantitative trait loci affecting approximately 17% of expressed genes, often with heteroalleic interactions.

Suggested Citation

  • Enrico Cannavò & Nils Koelling & Dermot Harnett & David Garfield & Francesco P. Casale & Lucia Ciglar & Hilary E. Gustafson & Rebecca R. Viales & Raquel Marco-Ferreres & Jacob F. Degner & Bingqing Zha, 2017. "Genetic variants regulating expression levels and isoform diversity during embryogenesis," Nature, Nature, vol. 541(7637), pages 402-406, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7637:d:10.1038_nature20802
    DOI: 10.1038/nature20802
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