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A 17-gene stemness score for rapid determination of risk in acute leukaemia

Author

Listed:
  • Stanley W. K. Ng

    (Institute of Biomaterials and Biomedical Engineering, University of Toronto)

  • Amanda Mitchell

    (Princess Margaret Cancer Centre, University Health Network)

  • James A. Kennedy

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto)

  • Weihsu C. Chen

    (Princess Margaret Cancer Centre, University Health Network)

  • Jessica McLeod

    (Princess Margaret Cancer Centre, University Health Network)

  • Narmin Ibrahimova

    (Princess Margaret Cancer Centre, University Health Network)

  • Andrea Arruda

    (Princess Margaret Cancer Centre, University Health Network)

  • Andreea Popescu

    (Princess Margaret Cancer Centre, University Health Network)

  • Vikas Gupta

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto)

  • Aaron D. Schimmer

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto
    University of Toronto)

  • Andre C. Schuh

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto)

  • Karen W. Yee

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto)

  • Lars Bullinger

    (University Hospital of Ulm)

  • Tobias Herold

    (University of Munich
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

  • Dennis Görlich

    (Institute of Biostatistics and Clinical Research, University of Münster)

  • Thomas Büchner

    (Hematology and Oncology, University of Münster)

  • Wolfgang Hiddemann

    (University of Munich
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

  • Wolfgang E. Berdel

    (Hematology and Oncology, University of Münster)

  • Bernhard Wörmann

    (Oncology and Tumor Immunology, Charité University Medicine, Campus Virchow)

  • Meyling Cheok

    (Jean-Pierre AUBERT Research Center UMR-S 1172, Institute for Cancer Research Lille)

  • Claude Preudhomme

    (University Hospital of Lille, Center of Pathology, Laboratory of Hematology)

  • Hervé Dombret

    (Saint-Louis Hospital, University of Paris Diderot)

  • Klaus Metzeler

    (University of Munich
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

  • Christian Buske

    (Comprehensive Cancer Center Ulm, Institute of Experimental Cancer Research, University Hospital of Ulm)

  • Bob Löwenberg

    (Erasmus University Medical Centre)

  • Peter J. M. Valk

    (Erasmus University Medical Centre)

  • Peter W. Zandstra

    (Institute of Biomaterials and Biomedical Engineering, University of Toronto)

  • Mark D. Minden

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto
    University of Toronto)

  • John E. Dick

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • Jean C. Y. Wang

    (Princess Margaret Cancer Centre, University Health Network
    University Health Network
    University of Toronto)

Abstract

A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

Suggested Citation

  • Stanley W. K. Ng & Amanda Mitchell & James A. Kennedy & Weihsu C. Chen & Jessica McLeod & Narmin Ibrahimova & Andrea Arruda & Andreea Popescu & Vikas Gupta & Aaron D. Schimmer & Andre C. Schuh & Karen, 2016. "A 17-gene stemness score for rapid determination of risk in acute leukaemia," Nature, Nature, vol. 540(7633), pages 433-437, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20598
    DOI: 10.1038/nature20598
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