IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v540y2016i7632d10.1038_nature20592.html
   My bibliography  Save this article

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Author

Listed:
  • Eunju Kang

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University
    †Present address: Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, South Korea.)

  • Jun Wu

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Nuria Marti Gutierrez

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Amy Koski

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Rebecca Tippner-Hedges

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Karen Agaronyan

    (Rowan University)

  • Aida Platero-Luengo

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Paloma Martinez-Redondo

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Hong Ma

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Yeonmi Lee

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University
    †Present address: Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, South Korea.)

  • Tomonari Hayama

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Crystal Van Dyken

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Xinjian Wang

    (Cincinnati Children’s Hospital Medical Center)

  • Shiyu Luo

    (Cincinnati Children’s Hospital Medical Center)

  • Riffat Ahmed

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Ying Li

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Dongmei Ji

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Reproductive Medical Centre, Anhui Medical University)

  • Refik Kayali

    (IviGen Los Angeles)

  • Cengiz Cinnioglu

    (IviGen Los Angeles)

  • Susan Olson

    (Research Cytogenetics Laboratory, Oregon Health & Science University)

  • Jeffrey Jensen

    (Oregon Health & Science University)

  • David Battaglia

    (Oregon Health & Science University)

  • David Lee

    (Oregon Health & Science University)

  • Diana Wu

    (Oregon Health & Science University)

  • Taosheng Huang

    (Cincinnati Children’s Hospital Medical Center)

  • Don P. Wolf

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Dmitry Temiakov

    (Rowan University)

  • Juan Carlos Izpisua Belmonte

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Paula Amato

    (Oregon Health & Science University)

  • Shoukhrat Mitalipov

    (Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University
    Oregon National Primate Research Center, Oregon Health & Science University
    Oregon Health & Science University
    Knight Cardiovascular Institute, Oregon Health & Science University)

Abstract

Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

Suggested Citation

  • Eunju Kang & Jun Wu & Nuria Marti Gutierrez & Amy Koski & Rebecca Tippner-Hedges & Karen Agaronyan & Aida Platero-Luengo & Paloma Martinez-Redondo & Hong Ma & Yeonmi Lee & Tomonari Hayama & Crystal Va, 2016. "Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations," Nature, Nature, vol. 540(7632), pages 270-275, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7632:d:10.1038_nature20592
    DOI: 10.1038/nature20592
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature20592
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature20592?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Liina Nagirnaja & Alexandra M. Lopes & Wu-Lin Charng & Brian Miller & Rytis Stakaitis & Ieva Golubickaite & Alexandra Stendahl & Tianpengcheng Luan & Corinna Friedrich & Eisa Mahyari & Eloise Fadial &, 2022. "Diverse monogenic subforms of human spermatogenic failure," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Ieva Keraite & Philipp Becker & Davide Canevazzi & Cristina Frias-López & Marc Dabad & Raúl Tonda-Hernandez & Ida Paramonov & Matthew John Ingham & Isabelle Brun-Heath & Jordi Leno & Anna Abulí & Elen, 2022. "A method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Robert Gajda & Aleksandra Samełko & Miłosz Czuba & Agnieszka Piotrowska-Nowak & Katarzyna Tońska & Cezary Żekanowski & Anna Klisiewicz & Wojciech Drygas & Anita Gębska-Kuczerowska & Jacek Gajda & Beat, 2021. "To Be a Champion of the 24-h Ultramarathon Race. If Not the Heart ... Mosaic Theory?," IJERPH, MDPI, vol. 18(5), pages 1-24, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:540:y:2016:i:7632:d:10.1038_nature20592. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.