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Capturing pairwise and multi-way chromosomal conformations using chromosomal walks

Author

Listed:
  • Pedro Olivares-Chauvet

    (Weizmann Institute)

  • Zohar Mukamel

    (Weizmann Institute)

  • Aviezer Lifshitz

    (Weizmann Institute)

  • Omer Schwartzman

    (Weizmann Institute)

  • Noa Oded Elkayam

    (Weizmann Institute)

  • Yaniv Lubling

    (Weizmann Institute)

  • Gintaras Deikus

    (Icahn Institute and Dept. of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai)

  • Robert P. Sebra

    (Icahn Institute and Dept. of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai)

  • Amos Tanay

    (Weizmann Institute)

Abstract

A conformation capture sequencing method is developed to link multiple genomic loci into three-dimensional proximity chains called chromosomal walks (C-walks), adding to our understanding of how higher-order chromosomal structures participate in genome regulation.

Suggested Citation

  • Pedro Olivares-Chauvet & Zohar Mukamel & Aviezer Lifshitz & Omer Schwartzman & Noa Oded Elkayam & Yaniv Lubling & Gintaras Deikus & Robert P. Sebra & Amos Tanay, 2016. "Capturing pairwise and multi-way chromosomal conformations using chromosomal walks," Nature, Nature, vol. 540(7632), pages 296-300, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7632:d:10.1038_nature20158
    DOI: 10.1038/nature20158
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    Citations

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    Cited by:

    1. Gabrielle A. Dotson & Can Chen & Stephen Lindsly & Anthony Cicalo & Sam Dilworth & Charles Ryan & Sivakumar Jeyarajan & Walter Meixner & Cooper Stansbury & Joshua Pickard & Nicholas Beckloff & Amit Su, 2022. "Deciphering multi-way interactions in the human genome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Nimrod Rappoport & Elad Chomsky & Takashi Nagano & Charlie Seibert & Yaniv Lubling & Yael Baran & Aviezer Lifshitz & Wing Leung & Zohar Mukamel & Ron Shamir & Peter Fraser & Amos Tanay, 2023. "Single cell Hi-C identifies plastic chromosome conformations underlying the gastrulation enhancer landscape," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jia-Yong Zhong & Longjian Niu & Zhuo-Bin Lin & Xin Bai & Ying Chen & Feng Luo & Chunhui Hou & Chuan-Le Xiao, 2023. "High-throughput Pore-C reveals the single-allele topology and cell type-specificity of 3D genome folding," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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